Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200280946> ?p ?o ?g. }
- W4200280946 abstract "Although many genes are known to influence sleep, when and how they impact sleep-regulatory circuits remain ill-defined. Here, we show that insomniac ( inc ), a conserved adaptor for the autism-associated Cul3 ubiquitin ligase, acts in a restricted period of neuronal development to impact sleep in adult Drosophila . The loss of inc causes structural and functional alterations within the mushroom body (MB), a center for sensory integration, associative learning, and sleep regulation. In inc mutants, MB neurons are produced in excess, develop anatomical defects that impede circuit assembly, and are unable to promote sleep when activated in adulthood. Our findings link neurogenesis and postmitotic development of sleep-regulatory neurons to their adult function and suggest that developmental perturbations of circuits that couple sensory inputs and sleep may underlie sleep dysfunction in neurodevelopmental disorders." @default.
- W4200280946 created "2021-12-31" @default.
- W4200280946 creator A5011941338 @default.
- W4200280946 creator A5020108407 @default.
- W4200280946 creator A5028126477 @default.
- W4200280946 creator A5071124328 @default.
- W4200280946 creator A5076994324 @default.
- W4200280946 date "2021-12-15" @default.
- W4200280946 modified "2023-10-18" @default.
- W4200280946 title "insomniac links the development and function of a sleep-regulatory circuit" @default.
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