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- W4200284476 abstract "Fungi are reported to cause a range of superficial to invasive human infections. These often result in high morbidity and at times mortality. Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. Fungi thrive in humid, nutrient-enriched areas. Such an environment is well-supported by the oral cavity. Despite this, there is a relatively low incidence of severe oral and periodontal fungal infections, attributed to the presence of antimicrobial peptides hosted by saliva, viz. histatin 5 (Hstn 5). It displays fungicidal activity against a variety of fungi including Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and unicellular yeast-like Saccharomyces cerevisiae. Candida albicans alone accounts for about 70% of all global fungal infections including periodontal disease. This review intends to discuss the scope of Hstn 5 as a novel recourse for the control of fungal infections." @default.
- W4200284476 created "2021-12-31" @default.
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- W4200284476 date "2021-12-12" @default.
- W4200284476 modified "2023-09-30" @default.
- W4200284476 title "Envisaging Antifungal Potential of Histatin 5: A Physiological Salivary Peptide" @default.
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- W4200284476 doi "https://doi.org/10.3390/jof7121070" @default.
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