Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200285665> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W4200285665 abstract "Abstract The Coalition for Epidemic Preparedness Innovations’ ‘100-day moonshot’ aspires to launch a new vaccine within 100 days of pathogen identification. Here, we describe work to optimize adenovirus vector manufacturing for rapid response, by minimizing time to clinical trial and first large-scale supply, and maximizing the output from the available manufacturing footprint. We describe a rapid viral seed expansion workflow that allows vaccine release to clinical trials within 60 days of antigen sequence identification, followed by vaccine release from globally distributed sites within a further 40 days. We also describe a new perfusion-based upstream production process, designed to maximize output while retaining simplicity and suitability for existing manufacturing facilities. This improves upstream volumetric productivity of ChAdOx1 nCoV-19 by around four-fold and remains compatible with the existing downstream process, yielding drug substance sufficient for 10000 doses from each liter of bioreactor capacity. Transition to a new production process across a large manufacturing network is a major task. In the short term, the rapid seed generation workflow could be used with the existing production process. We also use techno-economic modelling to show that, if linear scale-up were achieved, a single cleanroom containing two 2000 L bioreactors running our new perfusion-based process could supply bulk drug substance for around 120 million doses each month, costing <0.20 EUR/dose. We estimate that a manufacturing network with 32000 L of bioreactor capacity could release around 1 billion doses of a new vaccine within 130 days of genomic sequencing of a new pathogen, in a hypothetical ‘surge campaign’ with suitable prior preparation and resources, including adequate fill-and-finish capacity. This accelerated manufacturing process, along with other advantages such as thermal stability, supports the ongoing value of adenovirus-vectored vaccines as a rapidly adaptable and deployable platform for emergency response." @default.
- W4200285665 created "2021-12-31" @default.
- W4200285665 creator A5001967667 @default.
- W4200285665 creator A5015412088 @default.
- W4200285665 creator A5023652131 @default.
- W4200285665 creator A5030636881 @default.
- W4200285665 creator A5036949637 @default.
- W4200285665 creator A5038667460 @default.
- W4200285665 creator A5040991151 @default.
- W4200285665 creator A5042079141 @default.
- W4200285665 creator A5044936333 @default.
- W4200285665 creator A5055697536 @default.
- W4200285665 creator A5064651300 @default.
- W4200285665 creator A5068295442 @default.
- W4200285665 date "2021-12-23" @default.
- W4200285665 modified "2023-09-22" @default.
- W4200285665 title "Accelerating manufacturing to enable large-scale supply of a new adenovirus-vectored vaccine within 100 days" @default.
- W4200285665 cites W1977504181 @default.
- W4200285665 cites W1992632443 @default.
- W4200285665 cites W1995253852 @default.
- W4200285665 cites W2020294960 @default.
- W4200285665 cites W2020405271 @default.
- W4200285665 cites W2032952923 @default.
- W4200285665 cites W2049414850 @default.
- W4200285665 cites W2067651229 @default.
- W4200285665 cites W2112637529 @default.
- W4200285665 cites W2139976232 @default.
- W4200285665 cites W2943635785 @default.
- W4200285665 cites W3045724532 @default.
- W4200285665 cites W3131762051 @default.
- W4200285665 cites W3164587779 @default.
- W4200285665 cites W3182460416 @default.
- W4200285665 cites W3195069582 @default.
- W4200285665 cites W3198979718 @default.
- W4200285665 cites W3203037871 @default.
- W4200285665 cites W4226208081 @default.
- W4200285665 cites W654691995 @default.
- W4200285665 doi "https://doi.org/10.1101/2021.12.22.473478" @default.
- W4200285665 hasPublicationYear "2021" @default.
- W4200285665 type Work @default.
- W4200285665 citedByCount "3" @default.
- W4200285665 countsByYear W42002856652022 @default.
- W4200285665 countsByYear W42002856652023 @default.
- W4200285665 crossrefType "posted-content" @default.
- W4200285665 hasAuthorship W4200285665A5001967667 @default.
- W4200285665 hasAuthorship W4200285665A5015412088 @default.
- W4200285665 hasAuthorship W4200285665A5023652131 @default.
- W4200285665 hasAuthorship W4200285665A5030636881 @default.
- W4200285665 hasAuthorship W4200285665A5036949637 @default.
- W4200285665 hasAuthorship W4200285665A5038667460 @default.
- W4200285665 hasAuthorship W4200285665A5040991151 @default.
- W4200285665 hasAuthorship W4200285665A5042079141 @default.
- W4200285665 hasAuthorship W4200285665A5044936333 @default.
- W4200285665 hasAuthorship W4200285665A5055697536 @default.
- W4200285665 hasAuthorship W4200285665A5064651300 @default.
- W4200285665 hasAuthorship W4200285665A5068295442 @default.
- W4200285665 hasBestOaLocation W42002856651 @default.
- W4200285665 hasConcept C116834253 @default.
- W4200285665 hasConcept C117671659 @default.
- W4200285665 hasConcept C127413603 @default.
- W4200285665 hasConcept C144133560 @default.
- W4200285665 hasConcept C162853370 @default.
- W4200285665 hasConcept C164624739 @default.
- W4200285665 hasConcept C177212765 @default.
- W4200285665 hasConcept C41008148 @default.
- W4200285665 hasConcept C59822182 @default.
- W4200285665 hasConcept C77088390 @default.
- W4200285665 hasConcept C86803240 @default.
- W4200285665 hasConceptScore W4200285665C116834253 @default.
- W4200285665 hasConceptScore W4200285665C117671659 @default.
- W4200285665 hasConceptScore W4200285665C127413603 @default.
- W4200285665 hasConceptScore W4200285665C144133560 @default.
- W4200285665 hasConceptScore W4200285665C162853370 @default.
- W4200285665 hasConceptScore W4200285665C164624739 @default.
- W4200285665 hasConceptScore W4200285665C177212765 @default.
- W4200285665 hasConceptScore W4200285665C41008148 @default.
- W4200285665 hasConceptScore W4200285665C59822182 @default.
- W4200285665 hasConceptScore W4200285665C77088390 @default.
- W4200285665 hasConceptScore W4200285665C86803240 @default.
- W4200285665 hasLocation W42002856651 @default.
- W4200285665 hasOpenAccess W4200285665 @default.
- W4200285665 hasPrimaryLocation W42002856651 @default.
- W4200285665 hasRelatedWork W1544898319 @default.
- W4200285665 hasRelatedWork W2081035100 @default.
- W4200285665 hasRelatedWork W2361231798 @default.
- W4200285665 hasRelatedWork W2384869196 @default.
- W4200285665 hasRelatedWork W2497175360 @default.
- W4200285665 hasRelatedWork W2506306745 @default.
- W4200285665 hasRelatedWork W2899084033 @default.
- W4200285665 hasRelatedWork W2964552794 @default.
- W4200285665 hasRelatedWork W3118799476 @default.
- W4200285665 hasRelatedWork W3206324740 @default.
- W4200285665 isParatext "false" @default.
- W4200285665 isRetracted "false" @default.
- W4200285665 workType "article" @default.