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- W4200287712 endingPage "107901" @default.
- W4200287712 startingPage "107901" @default.
- W4200287712 abstract "The detection of pathogenic bacteria using biosensing techniques could be a potential alternative to traditional culture based methods. However, the low specificity and sensitivity of conventional biosensors, critically related to the choice of bio-recognition elements, limit their practical applicability. Mammalian antibodies have been widely investigated as biorecognition ligands due to high specificity and technological advancement in antibody production. However, antibody-based biosensors are not considered as an efficient approach due to the batch-to-batch inconsistencies as well as low stability. In recent years, antimicrobial peptides (AMPs) have been increasingly investigated as ligands as they have demonstrated high stability and possessed multiple sites for capturing bacteria. The conjugation of chemo-selective groups with AMPs has allowed effective immobilization of peptides on biosensor surface. However, the specificity of AMPs is a major concern for consideration as an efficient ligand. In this article, we have reviewed the advances and concerns, particularly the selectivity of AMPs for specific detection of pathogenic bacteria. This review also focuses the state-of-the-art mechanisms, challenges and prospects for designing potential AMP conjugated biosensors. The application of AMP in different biosensing transducers such as electrochemical, optical and piezoelectric varieties has been widely discussed. We argue that this review would provide insights to design and construct AMP conjugated biosensors for the pathogenic bacteria detection." @default.
- W4200287712 created "2021-12-31" @default.
- W4200287712 creator A5030063036 @default.
- W4200287712 creator A5049091002 @default.
- W4200287712 creator A5055616048 @default.
- W4200287712 creator A5071574858 @default.
- W4200287712 creator A5080590103 @default.
- W4200287712 date "2022-03-01" @default.
- W4200287712 modified "2023-10-18" @default.
- W4200287712 title "Antimicrobial peptides: Promising alternatives over conventional capture ligands for biosensor-based detection of pathogenic bacteria" @default.
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