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• W4200291218 endingPage "106052" @default.
• W4200291218 startingPage "106052" @default.
• W4200291218 abstract "Chlorine or chloric disinfectants are cost-effective disinfectants, which are widely used to disinfect domestic and industrial water. The residual chlorine levels in some of these waters have been proven toxic to several aquatic organisms; however, the molecular mechanisms of toxicity of residual chlorine to aquatic crustaceans, including Macrobrachium nipponense, an economically important freshwater prawn native to Asian countries, have not been investigated to date. Here, M. nipponense was exposed to 0.53 mg/L of residual chlorine, and comparative transcriptomics analyses were performed to determine their response mechanisms at the molecular level. Residual chlorine caused lethal effects on prawns. Furthermore, a total of 940 differentially expressed genes (DEGs), including 501 up-regulated and 439 down-regulated genes, were identified after 48 h of residual chlorine exposure compared to the control group. After enrichment analysis of GO (Gene Ontology) functions and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, identified DEGs were demonstrated to be associated with a variety of functions including exerting oxidoreductase activity, and participating in oxidation-reduction process. In addition, cytochrome P450 family 1 subfamily A1 (CYP1A1), glutathione S-transferase (GST), and glucuronosyltransferase (UGT) were enriched in the pathway of metabolism of xenobiotics by cytochrome P450. Furthermore, protein-protein interaction (PPI) network analysis revealed interactions among actin beta/gamma 1 (ACTB_G1) gene encoding protein and a series of multiple functional DEGs (e.g., hexokinase (HK), fructose 1,6-biphosphate-aldolase A (ALDOA), cytochrome c (CYC), and elongation factor 1-alpha (EEF1A)) encoding proteins. This study laid a theoretical foundation for safety evaluation of chlorinated aquatic water and further investigation of the toxicity of chlorination to M. nipponense." @default.
• W4200291218 created "2021-12-31" @default.
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• W4200291218 date "2022-02-01" @default.
• W4200291218 modified "2023-09-26" @default.
• W4200291218 title "Molecular insight into the hepatopancreas of oriental river prawn (Macrobrachium nipponense) in response to residual chlorine stimulus" @default.
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• W4200291218 doi "https://doi.org/10.1016/j.aquatox.2021.106052" @default.
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