Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200291870> ?p ?o ?g. }
- W4200291870 endingPage "32" @default.
- W4200291870 startingPage "23" @default.
- W4200291870 abstract "Background Abdominal sepsis patients suffer from profound intravascular fluid deficit due to concomitant inflammatory response and capillary leakage. It is reported that anti-inflammatory properties of sedative agents can control inflammatory cascade in many experimental septic conditions. We aimed to investigate the best sedative drug for inflammatory responses and capillary leak in patients with abdominal sepsis.Methods In this prospective randomized study, 60 patients with abdominal sepsis who underwent abdominal surgery and required post-operative sedation and mechanical ventilation were randomized into 3 groups in a 1:1:1 ratio. Group D (sedated with dexmedetomidine), group P (sedated with propofol), and group M (sedated with midazolam). This study was held in intensive care units of Assiut University Hospitals with primary outcome was serum IL-6 and IL-1β. Secondary outcomes were capillary leak index, lactate clearance, vasopressor requirements, total intake, total output, and fluid balance.Results Dexmedetomidine significantly reduced levels of IL-6 and IL-1β through 48 hours compared to both midazolam and propofol. Dexmedetomidine caused a significant decline in capillary leak index (p < 0.05) through 48 hours and significant higher lactate clearance (p = 0.03) in first 24 hours compared to both midazolam and propofol. Dexmedetomidine group had a significantly lower intake in first 24 hours and comparable vasopressor requirements through 48 hours. Dexmedetomidine group had a significantly higher output, lower serum creatinine levels and lower positive fluid balance compared to propofol and midazolam.Conclusions Dexmedetomidine reduced inflammatory response and capillary leak in mechanically ventilated patients with abdominal sepsis with better lactate clearance and less fluid intake." @default.
- W4200291870 created "2021-12-31" @default.
- W4200291870 creator A5029350592 @default.
- W4200291870 creator A5052943678 @default.
- W4200291870 creator A5056994672 @default.
- W4200291870 creator A5078026899 @default.
- W4200291870 creator A5086332340 @default.
- W4200291870 creator A5087307938 @default.
- W4200291870 date "2021-12-20" @default.
- W4200291870 modified "2023-09-26" @default.
- W4200291870 title "Dexmedetomidine versus propofol or midazolam in patients with abdominal sepsis regarding inflammatory response and capillary leak" @default.
- W4200291870 cites W1525978695 @default.
- W4200291870 cites W1641381955 @default.
- W4200291870 cites W1857625750 @default.
- W4200291870 cites W1898928487 @default.
- W4200291870 cites W1973798824 @default.
- W4200291870 cites W1991255193 @default.
- W4200291870 cites W2033899624 @default.
- W4200291870 cites W2034358750 @default.
- W4200291870 cites W2039311893 @default.
- W4200291870 cites W2041322579 @default.
- W4200291870 cites W2054368495 @default.
- W4200291870 cites W2055740572 @default.
- W4200291870 cites W2062677763 @default.
- W4200291870 cites W2084549518 @default.
- W4200291870 cites W2087743107 @default.
- W4200291870 cites W2089458195 @default.
- W4200291870 cites W2111523345 @default.
- W4200291870 cites W2117219797 @default.
- W4200291870 cites W2123095004 @default.
- W4200291870 cites W2263718856 @default.
- W4200291870 cites W2280404143 @default.
- W4200291870 cites W2614578436 @default.
- W4200291870 cites W2767929859 @default.
- W4200291870 cites W2785304566 @default.
- W4200291870 cites W2794439571 @default.
- W4200291870 cites W2805220722 @default.
- W4200291870 cites W2807356795 @default.
- W4200291870 cites W2911496224 @default.
- W4200291870 cites W2940549594 @default.
- W4200291870 cites W3000640201 @default.
- W4200291870 cites W3016555942 @default.
- W4200291870 cites W3042981580 @default.
- W4200291870 cites W3047955255 @default.
- W4200291870 cites W3090090861 @default.
- W4200291870 cites W3118577024 @default.
- W4200291870 cites W3135021046 @default.
- W4200291870 cites W4247943214 @default.
- W4200291870 doi "https://doi.org/10.1080/11101849.2021.2006468" @default.
- W4200291870 hasPublicationYear "2021" @default.
- W4200291870 type Work @default.
- W4200291870 citedByCount "1" @default.
- W4200291870 countsByYear W42002918702022 @default.
- W4200291870 crossrefType "journal-article" @default.
- W4200291870 hasAuthorship W4200291870A5029350592 @default.
- W4200291870 hasAuthorship W4200291870A5052943678 @default.
- W4200291870 hasAuthorship W4200291870A5056994672 @default.
- W4200291870 hasAuthorship W4200291870A5078026899 @default.
- W4200291870 hasAuthorship W4200291870A5086332340 @default.
- W4200291870 hasAuthorship W4200291870A5087307938 @default.
- W4200291870 hasBestOaLocation W42002918701 @default.
- W4200291870 hasConcept C141071460 @default.
- W4200291870 hasConcept C2776277131 @default.
- W4200291870 hasConcept C2776814716 @default.
- W4200291870 hasConcept C2777602617 @default.
- W4200291870 hasConcept C2778000748 @default.
- W4200291870 hasConcept C2778384902 @default.
- W4200291870 hasConcept C2781302539 @default.
- W4200291870 hasConcept C42219234 @default.
- W4200291870 hasConcept C71924100 @default.
- W4200291870 hasConceptScore W4200291870C141071460 @default.
- W4200291870 hasConceptScore W4200291870C2776277131 @default.
- W4200291870 hasConceptScore W4200291870C2776814716 @default.
- W4200291870 hasConceptScore W4200291870C2777602617 @default.
- W4200291870 hasConceptScore W4200291870C2778000748 @default.
- W4200291870 hasConceptScore W4200291870C2778384902 @default.
- W4200291870 hasConceptScore W4200291870C2781302539 @default.
- W4200291870 hasConceptScore W4200291870C42219234 @default.
- W4200291870 hasConceptScore W4200291870C71924100 @default.
- W4200291870 hasFunder F4320335500 @default.
- W4200291870 hasIssue "1" @default.
- W4200291870 hasLocation W42002918701 @default.
- W4200291870 hasLocation W42002918702 @default.
- W4200291870 hasOpenAccess W4200291870 @default.
- W4200291870 hasPrimaryLocation W42002918701 @default.
- W4200291870 hasRelatedWork W2110127181 @default.
- W4200291870 hasRelatedWork W2367312788 @default.
- W4200291870 hasRelatedWork W2884670186 @default.
- W4200291870 hasRelatedWork W2938220967 @default.
- W4200291870 hasRelatedWork W3030850133 @default.
- W4200291870 hasRelatedWork W3045180314 @default.
- W4200291870 hasRelatedWork W3153296609 @default.
- W4200291870 hasRelatedWork W3195049410 @default.
- W4200291870 hasRelatedWork W4376223946 @default.
- W4200291870 hasRelatedWork W3198261604 @default.
- W4200291870 hasVolume "38" @default.
- W4200291870 isParatext "false" @default.
- W4200291870 isRetracted "false" @default.