Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200296515> ?p ?o ?g. }
- W4200296515 endingPage "3480" @default.
- W4200296515 startingPage "3480" @default.
- W4200296515 abstract "Obesity is associated with chronic low-grade inflammation. The benefits of exercise are partly attributed to its anti-inflammatory effect, but whether exercise can regulate NLRP3 inflammasome activation in obese adipose tissue remains unknown. Meteorin-like (METRNL), a recently discovered myokine, has been implicated in mediating the effect of exercise on metabolism. Herein, we examined the effect of exercise and METRNL on NLRP3 inflammasome activation. High-fat diet (HFD)-induced obese mice were subjected to treadmill exercise for 8 weeks. A subgroup of HFD mice was switched to normal chow with the exercise intervention. Exercise and diet attenuated weight gain, fat accumulation, and insulin resistance in obese mice. In addition, exercise downregulated gene and protein levels of inflammasome markers, including NLRP3 and caspase-1, in adipose tissue. In isolated bone marrow-derived macrophages, activation of NLRP3 inflammasome was suppressed in the exercise group, as confirmed by the downregulation of IL-1β and IL-18. Exercise significantly enhanced the expression of METRNL in various muscle depots, and further in vitro analysis revealed that recombinant METRNL treatment inhibited IL-1β secretion in macrophages. In conclusion, exercise exerts its anti-inflammatory action by suppressing adipose tissue NLRP3 inflammasome, and this is, in part, associated with METRNL induction in muscle and its anti-inflammatory effects in macrophages." @default.
- W4200296515 created "2021-12-31" @default.
- W4200296515 creator A5028564851 @default.
- W4200296515 creator A5050164340 @default.
- W4200296515 creator A5067754604 @default.
- W4200296515 creator A5091873351 @default.
- W4200296515 date "2021-12-09" @default.
- W4200296515 modified "2023-10-09" @default.
- W4200296515 title "Exercise Inhibits NLRP3 Inflammasome Activation in Obese Mice via the Anti-Inflammatory Effect of Meteorin-like" @default.
- W4200296515 cites W1561041814 @default.
- W4200296515 cites W1622905562 @default.
- W4200296515 cites W178098991 @default.
- W4200296515 cites W1864325817 @default.
- W4200296515 cites W1940950287 @default.
- W4200296515 cites W1951130782 @default.
- W4200296515 cites W1968604913 @default.
- W4200296515 cites W1975296966 @default.
- W4200296515 cites W1979514353 @default.
- W4200296515 cites W1982024216 @default.
- W4200296515 cites W2014859793 @default.
- W4200296515 cites W2025355874 @default.
- W4200296515 cites W2036681478 @default.
- W4200296515 cites W2044210137 @default.
- W4200296515 cites W2050315287 @default.
- W4200296515 cites W2053765200 @default.
- W4200296515 cites W2063111359 @default.
- W4200296515 cites W2073081893 @default.
- W4200296515 cites W2077332383 @default.
- W4200296515 cites W2086562954 @default.
- W4200296515 cites W2092328839 @default.
- W4200296515 cites W2098000380 @default.
- W4200296515 cites W2116932335 @default.
- W4200296515 cites W2117855475 @default.
- W4200296515 cites W2124848390 @default.
- W4200296515 cites W2141692232 @default.
- W4200296515 cites W2145404963 @default.
- W4200296515 cites W2150702412 @default.
- W4200296515 cites W2156510924 @default.
- W4200296515 cites W2222894597 @default.
- W4200296515 cites W2438628442 @default.
- W4200296515 cites W2564596224 @default.
- W4200296515 cites W2568378023 @default.
- W4200296515 cites W2573870881 @default.
- W4200296515 cites W2770919725 @default.
- W4200296515 cites W2771687058 @default.
- W4200296515 cites W2800028591 @default.
- W4200296515 cites W2805701447 @default.
- W4200296515 cites W2888803530 @default.
- W4200296515 cites W2890380917 @default.
- W4200296515 cites W2894391873 @default.
- W4200296515 cites W2901434239 @default.
- W4200296515 cites W2915337547 @default.
- W4200296515 cites W2979416274 @default.
- W4200296515 cites W2995001440 @default.
- W4200296515 cites W3010915099 @default.
- W4200296515 cites W3011118375 @default.
- W4200296515 cites W3036935612 @default.
- W4200296515 cites W3038114785 @default.
- W4200296515 cites W3080725906 @default.
- W4200296515 cites W3081179084 @default.
- W4200296515 cites W3092636180 @default.
- W4200296515 cites W3092998012 @default.
- W4200296515 cites W3097691970 @default.
- W4200296515 cites W3106666665 @default.
- W4200296515 cites W3128087866 @default.
- W4200296515 cites W3131107794 @default.
- W4200296515 cites W3131126633 @default.
- W4200296515 cites W3132041500 @default.
- W4200296515 cites W4313335068 @default.
- W4200296515 doi "https://doi.org/10.3390/cells10123480" @default.
- W4200296515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943988" @default.
- W4200296515 hasPublicationYear "2021" @default.
- W4200296515 type Work @default.
- W4200296515 citedByCount "22" @default.
- W4200296515 countsByYear W42002965152022 @default.
- W4200296515 countsByYear W42002965152023 @default.
- W4200296515 crossrefType "journal-article" @default.
- W4200296515 hasAuthorship W4200296515A5028564851 @default.
- W4200296515 hasAuthorship W4200296515A5050164340 @default.
- W4200296515 hasAuthorship W4200296515A5067754604 @default.
- W4200296515 hasAuthorship W4200296515A5091873351 @default.
- W4200296515 hasBestOaLocation W42002965151 @default.
- W4200296515 hasConcept C104317684 @default.
- W4200296515 hasConcept C117365660 @default.
- W4200296515 hasConcept C126322002 @default.
- W4200296515 hasConcept C127561419 @default.
- W4200296515 hasConcept C134018914 @default.
- W4200296515 hasConcept C171089720 @default.
- W4200296515 hasConcept C185592680 @default.
- W4200296515 hasConcept C2776914184 @default.
- W4200296515 hasConcept C2777209026 @default.
- W4200296515 hasConcept C2779959927 @default.
- W4200296515 hasConcept C55493867 @default.
- W4200296515 hasConcept C71924100 @default.
- W4200296515 hasConceptScore W4200296515C104317684 @default.
- W4200296515 hasConceptScore W4200296515C117365660 @default.
- W4200296515 hasConceptScore W4200296515C126322002 @default.
- W4200296515 hasConceptScore W4200296515C127561419 @default.