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- W4200301272 startingPage "100971" @default.
- W4200301272 abstract "Aging is the major risk factor for neurodegenerative diseases, accelerated by excessive calorie consumption and sedentary lifestyles. Bioenergetic challenges such as intermittent fasting (IF) have shown to promote lifespan and healthspan via an adaptive stress response. Activity-dependent brain-derived neurotrophic factor (BDNF) has emerged as key regulator of cognitive performance and brain health. This review aims to investigate the pathophysiological mechanisms linking IF and cognitive function with a focus on the role of BDNF, evaluating evidence from pre-clinical and human studies. A systematic literature search was performed. 82 peer-reviewed papers were accepted, critically appraised and summarised in a narrative analysis. Aging-related loss of BDNF has been associated with reduced synaptic plasticity, memory and learning as well as increased risk of cognitive impairment and Alzheimer's disease. IF was consistently reported to upregulate BDNF and improve cognitive performance in animal models. Further research is required to assess cognitive outcomes of IF in humans." @default.
- W4200301272 created "2021-12-31" @default.
- W4200301272 creator A5007240987 @default.
- W4200301272 creator A5076604430 @default.
- W4200301272 date "2022-04-01" @default.
- W4200301272 modified "2023-10-10" @default.
- W4200301272 title "Intermittent fasting and cognitive performance – Targeting BDNF as potential strategy to optimise brain health" @default.
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- W4200301272 doi "https://doi.org/10.1016/j.yfrne.2021.100971" @default.
- W4200301272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34929259" @default.
- W4200301272 hasPublicationYear "2022" @default.
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