FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200302925> ?p ?o ?g. }

• W4200302925 abstract "The homeobox (HOX) gene family encodes highly conserved transcription factors, that play important roles in the morphogenesis and embryonic development of vertebrates. Mammals have four similar HOX gene clusters, HOXA, HOXB, HOXC, and HOXD, which are located on chromosomes 7, 17,12 and 2 and consist of 38 genes. Some of these genes were found to be significantly related to a variety of tumors; however, it remains unknown whether abnormal expression of the HOX gene family affects prognosis and the tumor microenvironment (TME) reshaping in colorectal cancer (CRC). Therefore, we conducted this systematic exploration to provide additional information for the above questions.RNA sequencing data from The Cancer Genome Atlas (TCGA) and mRNA expression data from Gene Expression Omnibus (GEO) combined with online tumor analysis databases (UALCAN, TIMER, PrognoScan) were utilized to explore the relationship among abnormal expression of HOX family genes, prognosis and the tumor immune microenvironment in CRC.1. Differential expression and prognosis analysis: 24 genes were significantly differentially expressed in CRC compared to adjacent normal tissues, and seven upregulated genes were significantly associated with poor survival. Among these seven genes, univariate and multivariate Cox regression analysis revealed that only high expression of HOXC6 significantly contributed to poor prognosis; 2. The influence of overexpressed HOXC6 on the pathway and TME: High HOXC6 expression was significantly related to the cytokine pathway and expression of T cell attraction chemokines, the infiltration ratio of immune cells, expression of immune checkpoint markers, tumor mutation burden (TMB) scores and microsatellite instability-high (MSI-H) scores; 3. Stratified analysis based on stages: In stage IV, HOXC6 overexpression had no significant impact on TMB, MSI-H, infiltration ratio of immune cells and response prediction of immune checkpoint blockers (ICBs), which contributed to significantly poor overall survival (OS).Seven differentially expressed HOX family genes had significantly worse prognoses. Among them, overexpressed HOXC6 contributed the most to poor OS. High expression of HOXC6 was significantly associated with high immunogenicity in nonmetastatic CRC. Further research on HOXC6 is therefore worthwhile to provide potential alternatives in CRC immunotherapy." @default.
• W4200302925 created "2021-12-31" @default.
• W4200302925 creator A5018496234 @default.
• W4200302925 creator A5040527192 @default.
• W4200302925 creator A5041719384 @default.
• W4200302925 creator A5048979361 @default.
• W4200302925 creator A5054897932 @default.
• W4200302925 creator A5062468723 @default.
• W4200302925 creator A5077767463 @default.
• W4200302925 date "2021-12-07" @default.
• W4200302925 modified "2023-10-03" @default.
• W4200302925 title "The Effects of Differentially-Expressed Homeobox Family Genes on the Prognosis and HOXC6 on Immune Microenvironment Orchestration in Colorectal Cancer" @default.
• W4200302925 cites W1940241680 @default.
• W4200302925 cites W2065701495 @default.
• W4200302925 cites W2103746815 @default.
• W4200302925 cites W2107665951 @default.
• W4200302925 cites W2337015381 @default.
• W4200302925 cites W2347101381 @default.
• W4200302925 cites W2562410867 @default.
• W4200302925 cites W2729023252 @default.
• W4200302925 cites W2760942750 @default.
• W4200302925 cites W2768892314 @default.
• W4200302925 cites W2886498337 @default.
• W4200302925 cites W2890119752 @default.
• W4200302925 cites W2896872272 @default.
• W4200302925 cites W2901513648 @default.
• W4200302925 cites W2909679049 @default.
• W4200302925 cites W2948024202 @default.
• W4200302925 cites W2960078024 @default.
• W4200302925 cites W2966214074 @default.
• W4200302925 cites W2966972050 @default.
• W4200302925 cites W2970536272 @default.
• W4200302925 cites W2971912764 @default.
• W4200302925 cites W2975736685 @default.
• W4200302925 cites W2979523220 @default.
• W4200302925 cites W2980845005 @default.
• W4200302925 cites W2990642872 @default.
• W4200302925 cites W3007076179 @default.
• W4200302925 cites W3011282746 @default.
• W4200302925 cites W3013707205 @default.
• W4200302925 cites W3021442601 @default.
• W4200302925 cites W3026725748 @default.
• W4200302925 cites W3081889824 @default.
• W4200302925 cites W3091949069 @default.
• W4200302925 cites W3119005666 @default.
• W4200302925 cites W3149370098 @default.
• W4200302925 cites W3151427897 @default.
• W4200302925 cites W3155701827 @default.
• W4200302925 cites W3155842542 @default.
• W4200302925 cites W3162365339 @default.
• W4200302925 cites W3162826700 @default.
• W4200302925 cites W3165838466 @default.
• W4200302925 cites W3178937216 @default.
• W4200302925 cites W3184734893 @default.
• W4200302925 cites W3190032669 @default.
• W4200302925 cites W3194590325 @default.
• W4200302925 cites W3195311356 @default.
• W4200302925 doi "https://doi.org/10.3389/fimmu.2021.781221" @default.
• W4200302925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34950145" @default.
• W4200302925 hasPublicationYear "2021" @default.
• W4200302925 type Work @default.
• W4200302925 citedByCount "7" @default.
• W4200302925 countsByYear W42003029252022 @default.
• W4200302925 countsByYear W42003029252023 @default.
• W4200302925 crossrefType "journal-article" @default.
• W4200302925 hasAuthorship W4200302925A5018496234 @default.
• W4200302925 hasAuthorship W4200302925A5040527192 @default.
• W4200302925 hasAuthorship W4200302925A5041719384 @default.
• W4200302925 hasAuthorship W4200302925A5048979361 @default.
• W4200302925 hasAuthorship W4200302925A5054897932 @default.
• W4200302925 hasAuthorship W4200302925A5062468723 @default.
• W4200302925 hasAuthorship W4200302925A5077767463 @default.
• W4200302925 hasBestOaLocation W42003029251 @default.
• W4200302925 hasConcept C104317684 @default.
• W4200302925 hasConcept C111039654 @default.
• W4200302925 hasConcept C121587040 @default.
• W4200302925 hasConcept C121608353 @default.
• W4200302925 hasConcept C150194340 @default.
• W4200302925 hasConcept C162317418 @default.
• W4200302925 hasConcept C18431079 @default.
• W4200302925 hasConcept C2776107976 @default.
• W4200302925 hasConcept C502942594 @default.
• W4200302925 hasConcept C526805850 @default.
• W4200302925 hasConcept C54355233 @default.
• W4200302925 hasConcept C86803240 @default.
• W4200302925 hasConcept C8891405 @default.
• W4200302925 hasConceptScore W4200302925C104317684 @default.
• W4200302925 hasConceptScore W4200302925C111039654 @default.
• W4200302925 hasConceptScore W4200302925C121587040 @default.
• W4200302925 hasConceptScore W4200302925C121608353 @default.
• W4200302925 hasConceptScore W4200302925C150194340 @default.
• W4200302925 hasConceptScore W4200302925C162317418 @default.
• W4200302925 hasConceptScore W4200302925C18431079 @default.
• W4200302925 hasConceptScore W4200302925C2776107976 @default.
• W4200302925 hasConceptScore W4200302925C502942594 @default.
• W4200302925 hasConceptScore W4200302925C526805850 @default.
• W4200302925 hasConceptScore W4200302925C54355233 @default.
• W4200302925 hasConceptScore W4200302925C86803240 @default.
• W4200302925 hasConceptScore W4200302925C8891405 @default.
• W4200302925 hasFunder F4320321001 @default.

• next