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- W4200306541 abstract "Abstract The size of the nucleus scales robustly with cell size so that the nuclear-to-cell volume ratio (N/C ratio) is maintained during cell growth in many cell types. The mechanism responsible for this scaling remains mysterious. Previous studies have established that the N/C ratio is not determined by DNA amount but is instead influenced by factors such as nuclear envelope mechanics and nuclear transport. Here, we developed a quantitative model for nuclear size control based upon colloid osmotic pressure and tested key predictions in the fission yeast Schizosaccharomyces pombe . This model posits that the N/C ratio is determined by the numbers of macromolecules in the nucleoplasm and cytoplasm. Osmotic shift experiments showed that the fission yeast nucleus behaves as an ideal osmometer whose volume is primarily dictated by osmotic forces. Inhibition of nuclear export caused accumulation of macromolecules and an increase in crowding in the nucleoplasm, leading to nuclear swelling. We further demonstrated that the N/C ratio is maintained by a homeostasis mechanism based upon synthesis of macromolecules during growth. These studies demonstrate the functions of colloid osmotic pressure in intracellular organization and size control." @default.
- W4200306541 created "2021-12-31" @default.
- W4200306541 creator A5012267642 @default.
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- W4200306541 creator A5079726051 @default.
- W4200306541 creator A5082789932 @default.
- W4200306541 creator A5089897009 @default.
- W4200306541 date "2021-12-07" @default.
- W4200306541 modified "2023-09-27" @default.
- W4200306541 title "Control of nuclear size by osmotic forces in <i>Schizosaccharomyces pombe</i>" @default.
- W4200306541 cites W1166991168 @default.
- W4200306541 cites W1185101214 @default.
- W4200306541 cites W1186411442 @default.
- W4200306541 cites W1540070193 @default.
- W4200306541 cites W1572472250 @default.
- W4200306541 cites W1594135844 @default.
- W4200306541 cites W1623913395 @default.
- W4200306541 cites W1745326736 @default.
- W4200306541 cites W1859662172 @default.
- W4200306541 cites W1966062610 @default.
- W4200306541 cites W1971337746 @default.
- W4200306541 cites W1976776824 @default.
- W4200306541 cites W1979547244 @default.
- W4200306541 cites W1981715749 @default.
- W4200306541 cites W1984887826 @default.
- W4200306541 cites W1996313023 @default.
- W4200306541 cites W2010399610 @default.
- W4200306541 cites W2010452487 @default.
- W4200306541 cites W2011532091 @default.
- W4200306541 cites W2016153572 @default.
- W4200306541 cites W2025140711 @default.
- W4200306541 cites W2028075953 @default.
- W4200306541 cites W2031506646 @default.
- W4200306541 cites W2041297088 @default.
- W4200306541 cites W2049883153 @default.
- W4200306541 cites W2057376462 @default.
- W4200306541 cites W2060318688 @default.
- W4200306541 cites W2061403457 @default.
- W4200306541 cites W2064105224 @default.
- W4200306541 cites W2066145562 @default.
- W4200306541 cites W2068310937 @default.
- W4200306541 cites W2070210672 @default.
- W4200306541 cites W2071452226 @default.
- W4200306541 cites W2071682607 @default.
- W4200306541 cites W2078768877 @default.
- W4200306541 cites W2081180790 @default.
- W4200306541 cites W2088595107 @default.
- W4200306541 cites W2097005988 @default.
- W4200306541 cites W2098145231 @default.
- W4200306541 cites W2099540110 @default.
- W4200306541 cites W2102917770 @default.
- W4200306541 cites W2109187641 @default.
- W4200306541 cites W2110056793 @default.
- W4200306541 cites W2116780962 @default.
- W4200306541 cites W2118744058 @default.
- W4200306541 cites W2129140439 @default.
- W4200306541 cites W2131187223 @default.
- W4200306541 cites W2134809769 @default.
- W4200306541 cites W2137753785 @default.
- W4200306541 cites W2144504620 @default.
- W4200306541 cites W2150684226 @default.
- W4200306541 cites W2151777559 @default.
- W4200306541 cites W2159100436 @default.
- W4200306541 cites W2162791825 @default.
- W4200306541 cites W2265708655 @default.
- W4200306541 cites W2398869870 @default.
- W4200306541 cites W2520345180 @default.
- W4200306541 cites W2559880634 @default.
- W4200306541 cites W2568283323 @default.
- W4200306541 cites W2599961504 @default.
- W4200306541 cites W2609529009 @default.
- W4200306541 cites W2809092342 @default.
- W4200306541 cites W2888577691 @default.
- W4200306541 cites W2899248065 @default.
- W4200306541 cites W2909378020 @default.
- W4200306541 cites W2910006335 @default.
- W4200306541 cites W2910129136 @default.
- W4200306541 cites W2914401773 @default.
- W4200306541 cites W2923742219 @default.
- W4200306541 cites W2941166073 @default.
- W4200306541 cites W2947420165 @default.
- W4200306541 cites W2951086310 @default.
- W4200306541 cites W2952278313 @default.
- W4200306541 cites W2952548757 @default.
- W4200306541 cites W2977158954 @default.
- W4200306541 cites W2981638747 @default.
- W4200306541 cites W2987483766 @default.
- W4200306541 cites W3032525205 @default.
- W4200306541 cites W3033386606 @default.
- W4200306541 cites W3096057968 @default.
- W4200306541 cites W3127014991 @default.
- W4200306541 cites W3160225587 @default.
- W4200306541 cites W3171006607 @default.
- W4200306541 cites W3187031148 @default.
- W4200306541 cites W3216409650 @default.
- W4200306541 cites W4239833133 @default.
- W4200306541 cites W4319290968 @default.
- W4200306541 doi "https://doi.org/10.1101/2021.12.05.471221" @default.
- W4200306541 hasPublicationYear "2021" @default.
- W4200306541 type Work @default.