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- W4200306556 endingPage "135" @default.
- W4200306556 startingPage "135" @default.
- W4200306556 abstract "Bicalutamide (Bic) is an androgen deprivation therapy (ADT) for treating prostate cancer, while ADT is potentially associated with acute kidney injury. Previously, we recognized Bic induced renal mitochondria dysfunction in vitro and in vivo via the ROS -HIF1α pathway. Whether OXPHOS complex, as well as mitochondrial dynamics, can be influenced by Bic via modulation of peroxisome proliferator-activated receptor coactivator 1α (PGC1α), NADPH oxidase 4 (Nox4), mitofusins 1/2 (MFN 1/2), optic atrophy 1 (OPA1), and sirtuins (SIRTs) has not been documented. Renal mesangial cell line was treated with Bic (30~60 μM) for the indicated time. SIRTs, complex I, mitochondrial dynamics- and oxidative stress-related proteins were analyzed. Bic dose-dependently reduced mitochondrial potential, but dose- and time-dependently suppressed translocase of the outer mitochondrial membrane member 20 (Tomm 20), complex I activity. Nox4 and glutathione lead to decreased NAD+/NADH ratio, with upregulated superoxide dismutase 2. SIRT1 was initially stimulated and then suppressed, while SIRT3 was time- and dose-dependently downregulated. PGC1α, MFN2, and OPA1 were all upregulated, with MFN1 and pro-fission dynamin-related protein I downregulated. Bic exhibits potential to damage mitochondria via destroying complex I, complex I activity, and mitochondrial dynamics. Long-term treatment with Bic should be carefully followed up." @default.
- W4200306556 created "2021-12-31" @default.
- W4200306556 creator A5026100424 @default.
- W4200306556 creator A5043418578 @default.
- W4200306556 creator A5049393498 @default.
- W4200306556 creator A5060111415 @default.
- W4200306556 creator A5063817160 @default.
- W4200306556 date "2021-12-27" @default.
- W4200306556 modified "2023-09-26" @default.
- W4200306556 title "Bicalutamide Exhibits Potential to Damage Kidney via Destroying Complex I and Affecting Mitochondrial Dynamics" @default.
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- W4200306556 doi "https://doi.org/10.3390/jcm11010135" @default.
- W4200306556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35011880" @default.
- W4200306556 hasPublicationYear "2021" @default.
- W4200306556 type Work @default.