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- W4200307411 abstract "A transition-metal and hydride-free reductive aldol reaction has been developed for the synthesis of biologically active 3,3'-disubstituted oxindoles from isatin derivatives using rongalite. In this protocol, rongalite plays a dual role as a hydride-free reducing agent and a C1 unit donor. This transition metal-free method enables the synthesis of a wide range of 3-hydroxy-3-hydroxymethyloxindoles and 3-amino-3-hydroxymethyloxindoles with 79-96% yields. One-pot reductive hydroxymethylation, inexpensive rongalite (ca. $0.03/1 g), mild reaction conditions and short reaction time are some of the key features of this synthetic method. This protocol is also applicable to gram scale synthesis." @default.
- W4200307411 created "2021-12-31" @default.
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- W4200307411 date "2022-01-01" @default.
- W4200307411 modified "2023-10-16" @default.
- W4200307411 title "Rongalite-induced transition-metal and hydride-free reductive aldol reaction: a rapid access to 3,3′-disubstituted oxindoles and its mechanistic studies" @default.
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- W4200307411 doi "https://doi.org/10.1039/d1ob02284a" @default.
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