Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200309204> ?p ?o ?g. }
- W4200309204 abstract "Pancreatic cancer is associated with highly malignant tumors and poor prognosis due to strong therapeutic resistance. Accumulating evidence shows that activated pancreatic stellate cells (PSC) play an important role in the malignant progression of pancreatic cancer. In recent years, the rapid development of single-cell sequencing technology has facilitated the analysis of PSC population heterogeneity, allowing for the elucidation of the relationship between different subsets of cells with tumor development and therapeutic resistance. Researchers have identified two spatially separated, functionally complementary, and reversible subtypes, namely myofibroblastic and inflammatory PSC. Myofibroblastic PSC produce large amounts of pro-fibroproliferative collagen fibers, whereas inflammatory PSC express large amounts of inflammatory cytokines. These distinct cell subtypes cooperate to create a microenvironment suitable for cancer cell survival. Therefore, further understanding of the differentiation of PSC and their distinct functions will provide insight into more effective treatment options for pancreatic cancer patients." @default.
- W4200309204 created "2021-12-31" @default.
- W4200309204 creator A5024120345 @default.
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- W4200309204 creator A5060575116 @default.
- W4200309204 creator A5074788913 @default.
- W4200309204 date "2021-12-20" @default.
- W4200309204 modified "2023-09-23" @default.
- W4200309204 title "Heterogeneous Pancreatic Stellate Cells Are Powerful Contributors to the Malignant Progression of Pancreatic Cancer" @default.
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