Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200313547> ?p ?o ?g. }
- W4200313547 endingPage "21" @default.
- W4200313547 startingPage "21" @default.
- W4200313547 abstract "Sleep is a state in which important restorative and anabolic processes occur. Understanding changes of these metabolic processes during the circadian rhythm in the brain is crucial to elucidate neurophysiological mechanisms important for sleep function. Investigation of amino acid modifications and dipeptides has recently emerged as a valuable approach in the metabolic profiling of the central nervous system. Nonetheless, very little is known about the effects of sleep on the brain levels of amino acid analogues. In the present study, we examined brain regional sleep-induced alterations selective for modified amino acids and dipeptides using Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) based metabolomics. Our approach enabled the detection and identification of numerous amino acid-containing metabolites in the cortex, the hippocampus, the midbrain, and the cerebellum. In particular, analogues of the aromatic amino acids phenylalanine, tyrosine and tryptophan were significantly altered during sleep in the investigated brain regions. Cortical levels of medium and long chain N-acyl glycines were higher during sleep. Regional specific changes were also detected, especially related to tyrosine analogues in the hippocampus and the cerebellum. Our findings demonstrate a strong correlation between circadian rhythms and amino acid metabolism specific for different brain regions that provide previously unknown insights in brain metabolism." @default.
- W4200313547 created "2021-12-31" @default.
- W4200313547 creator A5019118107 @default.
- W4200313547 creator A5021415325 @default.
- W4200313547 creator A5055196749 @default.
- W4200313547 creator A5081024969 @default.
- W4200313547 creator A5081736851 @default.
- W4200313547 date "2021-12-27" @default.
- W4200313547 modified "2023-10-15" @default.
- W4200313547 title "Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle" @default.
- W4200313547 cites W157425433 @default.
- W4200313547 cites W1975338628 @default.
- W4200313547 cites W2039696259 @default.
- W4200313547 cites W2041255286 @default.
- W4200313547 cites W2063789328 @default.
- W4200313547 cites W2072815824 @default.
- W4200313547 cites W2080046774 @default.
- W4200313547 cites W2081593743 @default.
- W4200313547 cites W2090389394 @default.
- W4200313547 cites W2091689748 @default.
- W4200313547 cites W2139925812 @default.
- W4200313547 cites W2163225965 @default.
- W4200313547 cites W2164960065 @default.
- W4200313547 cites W2271654630 @default.
- W4200313547 cites W2324021033 @default.
- W4200313547 cites W2474050011 @default.
- W4200313547 cites W2504691963 @default.
- W4200313547 cites W2534346109 @default.
- W4200313547 cites W2574583920 @default.
- W4200313547 cites W2621071512 @default.
- W4200313547 cites W2762575841 @default.
- W4200313547 cites W2767683865 @default.
- W4200313547 cites W2803664483 @default.
- W4200313547 cites W2810897951 @default.
- W4200313547 cites W2874779902 @default.
- W4200313547 cites W2884295860 @default.
- W4200313547 cites W2889053624 @default.
- W4200313547 cites W2902895348 @default.
- W4200313547 cites W2906504723 @default.
- W4200313547 cites W2911833800 @default.
- W4200313547 cites W2927639900 @default.
- W4200313547 cites W2941238267 @default.
- W4200313547 cites W2945804586 @default.
- W4200313547 cites W2952442557 @default.
- W4200313547 cites W2956080955 @default.
- W4200313547 cites W2972209026 @default.
- W4200313547 cites W2985897872 @default.
- W4200313547 cites W2992320504 @default.
- W4200313547 cites W3016200112 @default.
- W4200313547 cites W3020161996 @default.
- W4200313547 cites W3021521707 @default.
- W4200313547 cites W3023665039 @default.
- W4200313547 cites W3025883815 @default.
- W4200313547 cites W3025907102 @default.
- W4200313547 cites W3033025794 @default.
- W4200313547 cites W3034400668 @default.
- W4200313547 cites W3080168504 @default.
- W4200313547 cites W3093343775 @default.
- W4200313547 cites W3097321957 @default.
- W4200313547 cites W3159110533 @default.
- W4200313547 cites W3201452294 @default.
- W4200313547 cites W3201690972 @default.
- W4200313547 cites W3206687244 @default.
- W4200313547 cites W3213958563 @default.
- W4200313547 cites W4226175315 @default.
- W4200313547 cites W4238754411 @default.
- W4200313547 doi "https://doi.org/10.3390/metabo12010021" @default.
- W4200313547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35050142" @default.
- W4200313547 hasPublicationYear "2021" @default.
- W4200313547 type Work @default.
- W4200313547 citedByCount "6" @default.
- W4200313547 countsByYear W42003135472022 @default.
- W4200313547 countsByYear W42003135472023 @default.
- W4200313547 crossrefType "journal-article" @default.
- W4200313547 hasAuthorship W4200313547A5019118107 @default.
- W4200313547 hasAuthorship W4200313547A5021415325 @default.
- W4200313547 hasAuthorship W4200313547A5055196749 @default.
- W4200313547 hasAuthorship W4200313547A5081024969 @default.
- W4200313547 hasAuthorship W4200313547A5081736851 @default.
- W4200313547 hasBestOaLocation W42003135471 @default.
- W4200313547 hasConcept C111919701 @default.
- W4200313547 hasConcept C121446783 @default.
- W4200313547 hasConcept C126322002 @default.
- W4200313547 hasConcept C169760540 @default.
- W4200313547 hasConcept C185592680 @default.
- W4200313547 hasConcept C2775841894 @default.
- W4200313547 hasConcept C2776165026 @default.
- W4200313547 hasConcept C2777431362 @default.
- W4200313547 hasConcept C2777992278 @default.
- W4200313547 hasConcept C2779652256 @default.
- W4200313547 hasConcept C2781161787 @default.
- W4200313547 hasConcept C41008148 @default.
- W4200313547 hasConcept C515207424 @default.
- W4200313547 hasConcept C529278444 @default.
- W4200313547 hasConcept C55493867 @default.
- W4200313547 hasConcept C71924100 @default.
- W4200313547 hasConcept C86803240 @default.
- W4200313547 hasConceptScore W4200313547C111919701 @default.