Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200314020> ?p ?o ?g. }
- W4200314020 endingPage "923" @default.
- W4200314020 startingPage "913" @default.
- W4200314020 abstract "PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is constitutively degraded. However, despite rapid proteasomal clearance, cPINK1 still appears to exert quality control influence over the neuronal protein homeostasis network, including protein synthesis and degradation machineries. The cytoplasmic concentration and activity of this molecule is therefore a powerful sensor that coordinates aspects of mitochondrial and cellular health. In addition, full-length PINK1 is retained on the mitochondrial membrane following depolarisation, where it is a powerful inducer of multiple mitophagic pathways. This function is executed primarily through the phosphorylation of several ubiquitin ligases, including its most widely studied substrate Parkin. Furthermore, the phosphorylation of both pro- and anti-apoptotic proteins by mitochondrial PINK1 acts as a pro-cellular survival signal when faced with apoptotic stimuli. Through these varied roles PINK1 directly influences functions central to cell dysfunction in neurodegenerative disease." @default.
- W4200314020 created "2021-12-31" @default.
- W4200314020 creator A5032460292 @default.
- W4200314020 creator A5040493228 @default.
- W4200314020 creator A5045037139 @default.
- W4200314020 date "2021-12-01" @default.
- W4200314020 modified "2023-10-16" @default.
- W4200314020 title "PINK1 signalling in neurodegenerative disease" @default.
- W4200314020 cites W1527671059 @default.
- W4200314020 cites W1877873625 @default.
- W4200314020 cites W1877948328 @default.
- W4200314020 cites W1962054249 @default.
- W4200314020 cites W1965110900 @default.
- W4200314020 cites W1981224101 @default.
- W4200314020 cites W1986492199 @default.
- W4200314020 cites W1991264370 @default.
- W4200314020 cites W1992947862 @default.
- W4200314020 cites W1996625702 @default.
- W4200314020 cites W2012014117 @default.
- W4200314020 cites W2015011507 @default.
- W4200314020 cites W2019443416 @default.
- W4200314020 cites W2020722847 @default.
- W4200314020 cites W2043276141 @default.
- W4200314020 cites W2044893896 @default.
- W4200314020 cites W2045636730 @default.
- W4200314020 cites W2050849483 @default.
- W4200314020 cites W2052460507 @default.
- W4200314020 cites W2052889619 @default.
- W4200314020 cites W2053071811 @default.
- W4200314020 cites W2053680640 @default.
- W4200314020 cites W2055538245 @default.
- W4200314020 cites W2057713336 @default.
- W4200314020 cites W2058653820 @default.
- W4200314020 cites W2061330513 @default.
- W4200314020 cites W2072891641 @default.
- W4200314020 cites W2072990877 @default.
- W4200314020 cites W2074272918 @default.
- W4200314020 cites W2082425146 @default.
- W4200314020 cites W2086557228 @default.
- W4200314020 cites W2087592289 @default.
- W4200314020 cites W2089180401 @default.
- W4200314020 cites W2090505404 @default.
- W4200314020 cites W2103230459 @default.
- W4200314020 cites W2106142195 @default.
- W4200314020 cites W2106296386 @default.
- W4200314020 cites W2108900682 @default.
- W4200314020 cites W2110478458 @default.
- W4200314020 cites W2114687743 @default.
- W4200314020 cites W2117217282 @default.
- W4200314020 cites W2135592618 @default.
- W4200314020 cites W2140654974 @default.
- W4200314020 cites W2143161560 @default.
- W4200314020 cites W2148819754 @default.
- W4200314020 cites W2149761960 @default.
- W4200314020 cites W2150469601 @default.
- W4200314020 cites W2164945122 @default.
- W4200314020 cites W2167867141 @default.
- W4200314020 cites W2171213306 @default.
- W4200314020 cites W2185348657 @default.
- W4200314020 cites W2227316484 @default.
- W4200314020 cites W2317261522 @default.
- W4200314020 cites W2402960573 @default.
- W4200314020 cites W2415023963 @default.
- W4200314020 cites W2471742367 @default.
- W4200314020 cites W2508968739 @default.
- W4200314020 cites W2555953028 @default.
- W4200314020 cites W2593974461 @default.
- W4200314020 cites W2604819250 @default.
- W4200314020 cites W2605385415 @default.
- W4200314020 cites W2605825818 @default.
- W4200314020 cites W2614053601 @default.
- W4200314020 cites W2619986275 @default.
- W4200314020 cites W2726391040 @default.
- W4200314020 cites W2754823764 @default.
- W4200314020 cites W2755721896 @default.
- W4200314020 cites W2759679658 @default.
- W4200314020 cites W2772899687 @default.
- W4200314020 cites W2796906206 @default.
- W4200314020 cites W2805711807 @default.
- W4200314020 cites W2810701500 @default.
- W4200314020 cites W2865487305 @default.
- W4200314020 cites W2903556244 @default.
- W4200314020 cites W2905417282 @default.
- W4200314020 cites W2906265323 @default.
- W4200314020 cites W2945896312 @default.
- W4200314020 cites W2961957721 @default.
- W4200314020 cites W2965383452 @default.
- W4200314020 cites W2995096576 @default.
- W4200314020 cites W2995135670 @default.
- W4200314020 cites W3005606800 @default.
- W4200314020 cites W3009966546 @default.
- W4200314020 cites W3013202411 @default.
- W4200314020 cites W3016185846 @default.
- W4200314020 cites W3019624534 @default.
- W4200314020 cites W3027900078 @default.
- W4200314020 cites W3029175084 @default.
- W4200314020 cites W3043801178 @default.
- W4200314020 cites W3049506159 @default.