Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200314571> ?p ?o ?g. }
- W4200314571 abstract "When suffering from osteoarthritis (OA), articular cartilage homeostasis is out of balance and the living quality declines. The treatment of knee OA has always been an unsolved problem in the world. At present, symptomatic treatment is mainly adopted for OA. Drug therapy is mainly used to relieve pain symptoms, but often accompanied with adverse reactions; surgical treatment involves the problem of poor integration between the repaired or transplanted tissues and the natural cartilage, leading to the failure of repair. Biotherapy which aims to promote cartilage in situ regeneration and to restore endochondral homeostasis is expected to be an effective method for the prevention and treatment of OA. Disease-modifying osteoarthritis drugs (DMOADs) are intended for targeted treatment of OA. The DMOADs prevent excessive destruction of articular cartilage through anti-catabolism and stimulate tissue regeneration via excitoanabolic effects. Sprifermin (recombinant human FGF18, rhFGF18) is an effective DMOAD, which can not only promote the proliferation of articular chondrocyte and the synthesis of extracellular matrix, increase the thickness of cartilage in a dose-dependent manner, but also inhibit the activity of proteolytic enzymes and remarkedly slow down the degeneration of cartilage. This paper reviews the unique advantages of Sprifermin in repairing cartilage injury and improving cartilage homeostasis, aiming to provide an important strategy for the effective prevention and treatment of cartilage injury-related diseases." @default.
- W4200314571 created "2021-12-31" @default.
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- W4200314571 date "2021-12-14" @default.
- W4200314571 modified "2023-10-14" @default.
- W4200314571 title "Sprifermin: Effects on Cartilage Homeostasis and Therapeutic Prospects in Cartilage-Related Diseases" @default.
- W4200314571 cites W1540660017 @default.
- W4200314571 cites W1541952406 @default.
- W4200314571 cites W1551310212 @default.
- W4200314571 cites W1562872667 @default.
- W4200314571 cites W1862237385 @default.
- W4200314571 cites W1869625801 @default.
- W4200314571 cites W1989026904 @default.
- W4200314571 cites W2012702539 @default.
- W4200314571 cites W2016625153 @default.
- W4200314571 cites W2018208576 @default.
- W4200314571 cites W2021763774 @default.
- W4200314571 cites W2028585571 @default.
- W4200314571 cites W2036491373 @default.
- W4200314571 cites W2038773696 @default.
- W4200314571 cites W2047331853 @default.
- W4200314571 cites W2050387873 @default.
- W4200314571 cites W2076665011 @default.
- W4200314571 cites W2099596786 @default.
- W4200314571 cites W2100261712 @default.
- W4200314571 cites W2100948689 @default.
- W4200314571 cites W2108698814 @default.
- W4200314571 cites W2110143857 @default.
- W4200314571 cites W2120727763 @default.
- W4200314571 cites W2122165039 @default.
- W4200314571 cites W2127056741 @default.
- W4200314571 cites W2127718403 @default.
- W4200314571 cites W2133059769 @default.
- W4200314571 cites W2135543843 @default.
- W4200314571 cites W2136878446 @default.
- W4200314571 cites W2145545196 @default.
- W4200314571 cites W2148857381 @default.
- W4200314571 cites W2156512494 @default.
- W4200314571 cites W2212681443 @default.
- W4200314571 cites W2265239390 @default.
- W4200314571 cites W2332060795 @default.
- W4200314571 cites W2475242616 @default.
- W4200314571 cites W2481203471 @default.
- W4200314571 cites W2519481747 @default.
- W4200314571 cites W2521068002 @default.
- W4200314571 cites W2566421653 @default.
- W4200314571 cites W2588864866 @default.
- W4200314571 cites W2596302024 @default.
- W4200314571 cites W2610264303 @default.
- W4200314571 cites W2748888693 @default.
- W4200314571 cites W2762575819 @default.
- W4200314571 cites W2774728583 @default.
- W4200314571 cites W2787159600 @default.
- W4200314571 cites W2800356552 @default.
- W4200314571 cites W2801769827 @default.
- W4200314571 cites W2802018312 @default.
- W4200314571 cites W2802436949 @default.
- W4200314571 cites W2809177340 @default.
- W4200314571 cites W2883617845 @default.
- W4200314571 cites W2885136647 @default.
- W4200314571 cites W2890925893 @default.
- W4200314571 cites W2894318233 @default.
- W4200314571 cites W2894643726 @default.
- W4200314571 cites W2919287544 @default.
- W4200314571 cites W2922060164 @default.
- W4200314571 cites W2923178956 @default.
- W4200314571 cites W2937319242 @default.
- W4200314571 cites W2949475685 @default.
- W4200314571 cites W2955909334 @default.
- W4200314571 cites W2961082130 @default.
- W4200314571 cites W2969810988 @default.
- W4200314571 cites W2980134306 @default.
- W4200314571 cites W2981223988 @default.
- W4200314571 cites W2981437653 @default.
- W4200314571 cites W2984823884 @default.
- W4200314571 cites W2990637876 @default.
- W4200314571 cites W299190129 @default.
- W4200314571 cites W3002879789 @default.
- W4200314571 cites W3007795285 @default.
- W4200314571 cites W3014070799 @default.
- W4200314571 cites W3014848631 @default.
- W4200314571 cites W3018152496 @default.
- W4200314571 cites W3021629697 @default.
- W4200314571 cites W3021918898 @default.
- W4200314571 cites W3024460653 @default.
- W4200314571 cites W3038757200 @default.
- W4200314571 cites W3045331531 @default.
- W4200314571 cites W3049474785 @default.
- W4200314571 cites W3080524727 @default.
- W4200314571 cites W3084135978 @default.
- W4200314571 cites W3087917567 @default.
- W4200314571 cites W3090429615 @default.
- W4200314571 cites W3091562372 @default.