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- W4200316190 abstract "This book chapter discusses proteogenomics data integration and provides an overview into the different omics layer involved in defining the proteome of a living organism. Various aspects of genome variability affecting either the sequence or abundance level of proteins are discussed in this book chapter, such as the effect of single-nucleotide variants or larger genomic structural variants on the proteome. Next, various sequencing technologies are introduced and discussed from a proteogenomics data integration perspective such as those providing short- and long-read sequencing and listing their respective advantages and shortcomings for accurate protein variant prediction using genomic/transcriptomics sequencing data. Finally, the various bioinformatics tools used to process and analyze DNA/RNA sequencing data are discussed with the ultimate goal of obtaining accurately predicted sample-specific protein sequences that can be used as a drop-in replacement in existing approaches for peptide and protein identification using popular database search engines such as MSFragger, SearchGUI/PeptideShaker." @default.
- W4200316190 created "2021-12-31" @default.
- W4200316190 creator A5050979301 @default.
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- W4200316190 date "2021-12-15" @default.
- W4200316190 modified "2023-09-27" @default.
- W4200316190 title "Accurate Prediction of Protein Sequences for Proteogenomics Data Integration" @default.
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