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- W4200318095 abstract "Aquatic ecosystem has been reported to be the universal sufferer of pollution caused by direct exposure of industrial discharges which causes severe genotoxic damages to aquatic flora and fauna. Researchers have found that fish have been extensively harmed by such exposure compared to other aquatic fauna. As living organisms directly depend on fish as a food resource, hence the study of mutagenicity induced have been extensively important not only for safety of aquatic organisms but also for safety of other living organisms too. Micronucleus (MN) assay has been continuously used in the evaluation of DNA damage. Mutagenic and genotoxic studies employed this methodology to evaluate possible carcinogenic risk due to exposure to harmful xenobiotics in including aquatic organisms. The aim of this study was to monitor the level of genotoxicity induced in fishes due to exposure to local paper mill effluent by using micronucleus assay as a biomarker. Fish were exposed to different concentrations of PME as 10%, 25% and 50%. Variation of body weight, survivality rate and percentage of micronucleated PCEs were analyzed. One-way anova was performed and data were expressed as Mean± S.E. Consecutive dose dependent and time dependent increase of toxicity was recorded in PME compared to negative and positive control (Mitomycin C). Our study supported the carcinogenic and chromosomal damage induced in aquatic organisms specially in fishes due to direct exposure of industrial discharges; also, the importance of MN test as an effective indicator for testing genotoxicity in fishes was confirmed." @default.
- W4200318095 created "2021-12-31" @default.
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- W4200318095 date "2021-12-25" @default.
- W4200318095 modified "2023-10-18" @default.
- W4200318095 title "Ecotoxicological Risk Assessment of Paper Mill Effluent Waste Water" @default.
- W4200318095 doi "https://doi.org/10.21786/bbrc/14.4.57" @default.
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