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- W4200318223 abstract "A diaryl ketone series was identified as vanin-1 inhibitors from a high-throughput screening campaign. While this novel scaffold provided valuable probe 2 that was used to build target confidence, concerns over the ketone moiety led to the replacement of this group. The successful replacement of this moiety was achieved with pyrimidine carboxamides derived from cyclic secondary amines that were extensively characterized using biophysical and crystallographic methods as competitive inhibitors of vanin-1. Through optimization of potency and physicochemical and ADME properties, and guided by co-crystal structures with vanin-1, 3 was identified with a suitable profile for advancement into preclinical development." @default.
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- W4200318223 date "2021-12-30" @default.
- W4200318223 modified "2023-09-26" @default.
- W4200318223 title "Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1" @default.
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- W4200318223 doi "https://doi.org/10.1021/acs.jmedchem.1c01849" @default.
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