Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200318803> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4200318803 abstract "Abstract Background: Ferroptosis is a type of cell death accompanied by iron-dependent lipid peroxidation, however, how IR-induced ferroptosis is regulated in Hepatocellular carcinoma cells (HCC) remains largely unknown. We have previously found that adiponectin receptor 1(AdipoR1) might be a prognostic biomarker for HCC after stereotactic body radiotherapy (SBRT). In this study, we aimed to elucidate the roles of AdipoR1 in radiation-induced Ferroptosis of HCC. Methods: Human HCC cell line MHCC-97H and HepG2 and human hepatic cell lines LO2 were tested. qRT-PCR and western blotting were used to detect mRNA and protein expression respectively, colony formation assay was used to evaluate the radiosensitivity and flow cytometry was used to assess lipid peroxidation and cell death. Dual-Luciferase Reporter assay system was used to detect the transcription activity. Results: Ionizing Radiation (IR) upregulated the expression of AdipoR1 in HCC cells and AdipoR1 knockdown could promote radiation sensitivity of HCC cells. AdipoR1 knockdown could decrease the expression of Nrf2 and Nrf2 protein stability. Nrf2 could bind to xCT promoter and promoted the transcription and expression of xCT. AdipoR1 knockdown increased significantly lipid peroxidation and ferroptosis induced by IR or Erastin respectively, which could be abolished by overexpression of Nrf2 and xCT. Conclusion: AdipoR1 knockdown can promote radiation sensitivity of HCC cells; AdipoR1 regulates IR-induced cell death by AdipoR1-Nrf2-xCT pathway." @default.
- W4200318803 created "2021-12-31" @default.
- W4200318803 creator A5008659449 @default.
- W4200318803 creator A5008779746 @default.
- W4200318803 creator A5016556832 @default.
- W4200318803 creator A5018855499 @default.
- W4200318803 creator A5034182089 @default.
- W4200318803 creator A5035168940 @default.
- W4200318803 creator A5047063645 @default.
- W4200318803 creator A5064228800 @default.
- W4200318803 creator A5073534113 @default.
- W4200318803 creator A5073871710 @default.
- W4200318803 creator A5081675173 @default.
- W4200318803 creator A5085267077 @default.
- W4200318803 date "2021-12-29" @default.
- W4200318803 modified "2023-10-18" @default.
- W4200318803 title "AdipoR1 Regulates Ionizing Radiation-Induced Ferroptosis in HCC Cells Through Nrf2/xCT Pathway" @default.
- W4200318803 doi "https://doi.org/10.21203/rs.3.rs-1176723/v1" @default.
- W4200318803 hasPublicationYear "2021" @default.
- W4200318803 type Work @default.
- W4200318803 citedByCount "0" @default.
- W4200318803 crossrefType "posted-content" @default.
- W4200318803 hasAuthorship W4200318803A5008659449 @default.
- W4200318803 hasAuthorship W4200318803A5008779746 @default.
- W4200318803 hasAuthorship W4200318803A5016556832 @default.
- W4200318803 hasAuthorship W4200318803A5018855499 @default.
- W4200318803 hasAuthorship W4200318803A5034182089 @default.
- W4200318803 hasAuthorship W4200318803A5035168940 @default.
- W4200318803 hasAuthorship W4200318803A5047063645 @default.
- W4200318803 hasAuthorship W4200318803A5064228800 @default.
- W4200318803 hasAuthorship W4200318803A5073534113 @default.
- W4200318803 hasAuthorship W4200318803A5073871710 @default.
- W4200318803 hasAuthorship W4200318803A5081675173 @default.
- W4200318803 hasAuthorship W4200318803A5085267077 @default.
- W4200318803 hasBestOaLocation W42003188031 @default.
- W4200318803 hasConcept C111337013 @default.
- W4200318803 hasConcept C121332964 @default.
- W4200318803 hasConcept C153911025 @default.
- W4200318803 hasConcept C173396325 @default.
- W4200318803 hasConcept C18231593 @default.
- W4200318803 hasConcept C185544564 @default.
- W4200318803 hasConcept C185592680 @default.
- W4200318803 hasConcept C190283241 @default.
- W4200318803 hasConcept C2776151105 @default.
- W4200318803 hasConcept C2780829032 @default.
- W4200318803 hasConcept C31573885 @default.
- W4200318803 hasConcept C502942594 @default.
- W4200318803 hasConcept C54355233 @default.
- W4200318803 hasConcept C553184892 @default.
- W4200318803 hasConcept C55493867 @default.
- W4200318803 hasConcept C81885089 @default.
- W4200318803 hasConcept C86803240 @default.
- W4200318803 hasConceptScore W4200318803C111337013 @default.
- W4200318803 hasConceptScore W4200318803C121332964 @default.
- W4200318803 hasConceptScore W4200318803C153911025 @default.
- W4200318803 hasConceptScore W4200318803C173396325 @default.
- W4200318803 hasConceptScore W4200318803C18231593 @default.
- W4200318803 hasConceptScore W4200318803C185544564 @default.
- W4200318803 hasConceptScore W4200318803C185592680 @default.
- W4200318803 hasConceptScore W4200318803C190283241 @default.
- W4200318803 hasConceptScore W4200318803C2776151105 @default.
- W4200318803 hasConceptScore W4200318803C2780829032 @default.
- W4200318803 hasConceptScore W4200318803C31573885 @default.
- W4200318803 hasConceptScore W4200318803C502942594 @default.
- W4200318803 hasConceptScore W4200318803C54355233 @default.
- W4200318803 hasConceptScore W4200318803C553184892 @default.
- W4200318803 hasConceptScore W4200318803C55493867 @default.
- W4200318803 hasConceptScore W4200318803C81885089 @default.
- W4200318803 hasConceptScore W4200318803C86803240 @default.
- W4200318803 hasLocation W42003188031 @default.
- W4200318803 hasLocation W42003188032 @default.
- W4200318803 hasOpenAccess W4200318803 @default.
- W4200318803 hasPrimaryLocation W42003188031 @default.
- W4200318803 hasRelatedWork W1529578025 @default.
- W4200318803 hasRelatedWork W2053279347 @default.
- W4200318803 hasRelatedWork W2067038367 @default.
- W4200318803 hasRelatedWork W2106564520 @default.
- W4200318803 hasRelatedWork W2328524531 @default.
- W4200318803 hasRelatedWork W2374966914 @default.
- W4200318803 hasRelatedWork W2403432132 @default.
- W4200318803 hasRelatedWork W3127192594 @default.
- W4200318803 hasRelatedWork W4200546529 @default.
- W4200318803 hasRelatedWork W4283693058 @default.
- W4200318803 isParatext "false" @default.
- W4200318803 isRetracted "false" @default.
- W4200318803 workType "article" @default.