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- W4200318852 abstract "Abstract Background Psoriasis is a common chronic inflammatory disease caused by excessive activation of CD4 + T cells, including Th17, Th1 and Th22. The role of CD8 + T cells in psoriasis pathogenesis remains poorly understood. Aim To identify the phenotype of CD8 + T cells in patients with psoriasis and to investigate its role in the formation of lesions. Methods The phenotype of CD8 + T cells in psoriatic lesions was detected by immunofluorescence staining. Flow cytometry was performed to detect their phenotype in peripheral blood. Thereafter, coculture of CD8αα + T cells with autogenous CD4 + T cells was performed to investigate the function of CD8αα + T cells in patients with psoriasis. Finally, pro‐inflammatory factors produced by CD8αα + T cells were examined by immunofluorescence staining and flow cytometry. Results Compared to the CD8αβ + T cells, CD8αα + T cell infiltration in psoriatic lesions markedly increased. Moreover, epidermal CD8αα + T cells exhibited tissue‐resident memory T cells (T RM ) phenotypes and dermal CD8αα + T cells exhibited effector memory (T EM ) phenotypes in psoriatic lesions. Additionally, we found that CD8αα + T cells from patients with psoriasis did not express the markers of regulatory T cells and could promote the proliferation of CD4 + T effector cells and produce interleukin‐17 and interferon‐γ. Conclusions Our findings demonstrate that CD8αα + T cells contribute to the pathogenesis of psoriasis by producing pro‐inflammatory factors." @default.
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- W4200318852 date "2021-11-16" @default.
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- W4200318852 title "CD8αα<sup>+</sup>T cells exert a pro‐inflammatory role in patients with psoriasis" @default.
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- W4200318852 doi "https://doi.org/10.1002/ski2.64" @default.
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