FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200320859> ?p ?o ?g. }

• W4200320859 abstract "The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward. The type 1 cannabinoid receptor (CB1R) and both subtypes of the orexin receptor, orexin receptor type 1 (OX1R) and orexin receptor type 2 (OX2R) are not only expressed in the same brain regions modulating these functions, but physically interact as heterodimers in recombinant and neuronal cell cultures. In the current study, male and female C57BL/6 mice were co-treated with the cannabinoid receptor agonist CP55,940 and either the OX2R antagonist TCS-OX2-29 or the dual orexin receptor antagonist (DORA) TCS-1102. Mice were then evaluated for catalepsy, body temperature, thermal anti-nociception, and locomotion, after which their brains were collected for receptor colocalization analysis. Combined treatment with the DORA TCS-1102 and CP55,940 potentiated catalepsy more than CP55,940 alone, but this effect was not observed for changes in body temperature, nociception, locomotion, or via selective OX2R antagonism. Co-treatment with CP55,940 and TCS-1102 also led to increased CB1R-OX1R colocalization in the ventral striatum. This was not seen following co-treatment with TCS-OX2-29, nor in CB1R-OX2R colocalization. The magnitude of effects following co-treatment with CP55,940 and either the DORA or OX2R-selective antagonist was greater in males than females. These data show that CB1R-OX1R colocalization in the ventral striatum underlies cataleptic additivity between CP55,940 and the DORA TCS-1102. Moreover, cannabinoid-orexin receptor interactions are sex-specific with regards to brain region and functionality. Physical or molecular interactions between these two systems may provide valuable insight into drug-drug interactions between cannabinoid and orexin drugs for the treatment of insomnia, pain, and other disorders." @default.
• W4200320859 created "2021-12-31" @default.
• W4200320859 creator A5009359082 @default.
• W4200320859 creator A5012904566 @default.
• W4200320859 creator A5027458374 @default.
• W4200320859 creator A5037819900 @default.
• W4200320859 creator A5046479353 @default.
• W4200320859 creator A5055187683 @default.
• W4200320859 creator A5069710197 @default.
• W4200320859 date "2021-12-21" @default.
• W4200320859 modified "2023-09-27" @default.
• W4200320859 title "In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors" @default.
• W4200320859 cites W1900806505 @default.
• W4200320859 cites W1972747431 @default.
• W4200320859 cites W1977320288 @default.
• W4200320859 cites W1987987090 @default.
• W4200320859 cites W2001617746 @default.
• W4200320859 cites W2013655437 @default.
• W4200320859 cites W2013679503 @default.
• W4200320859 cites W2016202053 @default.
• W4200320859 cites W2028409686 @default.
• W4200320859 cites W2032416963 @default.
• W4200320859 cites W2041731336 @default.
• W4200320859 cites W2049464937 @default.
• W4200320859 cites W2056795643 @default.
• W4200320859 cites W2058910991 @default.
• W4200320859 cites W2059178792 @default.
• W4200320859 cites W2068195538 @default.
• W4200320859 cites W2071835207 @default.
• W4200320859 cites W2075515027 @default.
• W4200320859 cites W2078051508 @default.
• W4200320859 cites W2079847109 @default.
• W4200320859 cites W2082629022 @default.
• W4200320859 cites W2085060963 @default.
• W4200320859 cites W2092804224 @default.
• W4200320859 cites W2097943546 @default.
• W4200320859 cites W2098040987 @default.
• W4200320859 cites W2106861335 @default.
• W4200320859 cites W2111723991 @default.
• W4200320859 cites W2116562654 @default.
• W4200320859 cites W2126766019 @default.
• W4200320859 cites W2131850887 @default.
• W4200320859 cites W2135298466 @default.
• W4200320859 cites W2143609607 @default.
• W4200320859 cites W2149183149 @default.
• W4200320859 cites W2152807333 @default.
• W4200320859 cites W2162670271 @default.
• W4200320859 cites W2176414126 @default.
• W4200320859 cites W2297452983 @default.
• W4200320859 cites W2481888157 @default.
• W4200320859 cites W2573471063 @default.
• W4200320859 cites W2593619809 @default.
• W4200320859 cites W2597479008 @default.
• W4200320859 cites W2626033047 @default.
• W4200320859 cites W2733461110 @default.
• W4200320859 cites W2778527301 @default.
• W4200320859 cites W2887753993 @default.
• W4200320859 cites W2889383596 @default.
• W4200320859 cites W2897353348 @default.
• W4200320859 cites W2898435838 @default.
• W4200320859 cites W2971595373 @default.
• W4200320859 cites W3006861050 @default.
• W4200320859 cites W3036840313 @default.
• W4200320859 cites W3104573036 @default.
• W4200320859 cites W3109480914 @default.
• W4200320859 cites W3127151238 @default.
• W4200320859 cites W3161273037 @default.
• W4200320859 cites W3173262986 @default.
• W4200320859 cites W4296816736 @default.
• W4200320859 cites W82550095 @default.
• W4200320859 doi "https://doi.org/10.3389/fnins.2021.790546" @default.
• W4200320859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34992518" @default.
• W4200320859 hasPublicationYear "2021" @default.
• W4200320859 type Work @default.
• W4200320859 citedByCount "4" @default.
• W4200320859 countsByYear W42003208592022 @default.
• W4200320859 countsByYear W42003208592023 @default.
• W4200320859 crossrefType "journal-article" @default.
• W4200320859 hasAuthorship W4200320859A5009359082 @default.
• W4200320859 hasAuthorship W4200320859A5012904566 @default.
• W4200320859 hasAuthorship W4200320859A5027458374 @default.
• W4200320859 hasAuthorship W4200320859A5037819900 @default.
• W4200320859 hasAuthorship W4200320859A5046479353 @default.
• W4200320859 hasAuthorship W4200320859A5055187683 @default.
• W4200320859 hasAuthorship W4200320859A5069710197 @default.
• W4200320859 hasBestOaLocation W42003208591 @default.
• W4200320859 hasConcept C118303440 @default.
• W4200320859 hasConcept C126322002 @default.
• W4200320859 hasConcept C148001335 @default.
• W4200320859 hasConcept C169760540 @default.
• W4200320859 hasConcept C170493617 @default.
• W4200320859 hasConcept C185592680 @default.
• W4200320859 hasConcept C2778938600 @default.
• W4200320859 hasConcept C2779605129 @default.
• W4200320859 hasConcept C2779680196 @default.
• W4200320859 hasConcept C2780433416 @default.
• W4200320859 hasConcept C2780871563 @default.
• W4200320859 hasConcept C40209533 @default.
• W4200320859 hasConcept C46721173 @default.
• W4200320859 hasConcept C71924100 @default.

• next