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- W4200320912 abstract "In the present study, fibrin-based biomaterials made of zeolite imidazole framework-8 (ZIF-8) and fibrin gel (Z-FG) are fabricated with the aim of enhancing skull regeneration. X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet (UV)-vis spectrophotometry, Fourier transform infrared spectroscopy, and rheometry are used to characterize ZIF-8 and Z-FG. The influences of ZIF-8 on the physical properties of fibrin gel (e.g., porosity, modulus, and in vitro biodegradation) are investigated, and the effect of ZIF-8 concentration on fibrin gel properties in vitro is determined by seeding ectomesenchymal stem cells (EMSCs) over Z-FG. EMSC osteogenic differentiation reveals higher expression of bone-related proteins and higher calcium deposition and alkaline phosphatase activity, indicating that Z-FG may be a good osteoinductive biomaterial. Furthermore, these results show that the piezochannel and yes-associated protein (YAP) signaling pathway are involved in the differentiation process. In addition, the in vivo results demonstrate that Z-FG increases bone formation in critical-sized calvarial defects in rats. Thus, the developed composite scaffold may be a suitable biomaterial for skull tissue-engineering applications." @default.
- W4200320912 created "2021-12-31" @default.
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- W4200320912 date "2022-01-11" @default.
- W4200320912 modified "2023-09-28" @default.
- W4200320912 title "Enhanced Bone Regeneration Using a ZIF‐8‐Loaded Fibrin Composite Scaffold" @default.
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- W4200320912 doi "https://doi.org/10.1002/mabi.202100416" @default.
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