Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200321444> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4200321444 abstract "Vestibular schwannomas (VSs) represent Schwann cell (SC) tumors of the vestibular nerve, compromising 10% of all intracranial neoplasms. VSs occur in either sporadic or familial (neurofibromatosis type 2, NF2) forms, both associated with inactivating defects in the NF2 tumor suppressor gene. Treatment for VSs is generally surgical resection or radiosurgery, however the morbidity of such procedures has driven investigations into less invasive treatments. Historically, lack of access to fresh tissue specimens and the fact that schwannoma cells are not immortalized have significantly hampered the use of primary cultures for investigation of schwannoma tumorigenesis. To overcome the limited supply of primary cultures, the immortalized HEI193 VS cell line was generated by transduction with HPV E6 and E7 oncogenes. This oncogenic transduction introduced significant molecular and phenotypic alterations to the cells, which limit their use as a model for human schwannoma tumors. We therefore illustrate a simplified, reproducible protocol for culture of primary human VS cells. This easily mastered technique allows for molecular and cellular investigations that more accurately recapitulate the complexity of VS disease." @default.
- W4200321444 created "2021-12-31" @default.
- W4200321444 creator A5012784574 @default.
- W4200321444 creator A5034747659 @default.
- W4200321444 creator A5075761198 @default.
- W4200321444 date "2014-07-20" @default.
- W4200321444 modified "2023-09-26" @default.
- W4200321444 title "Primary Culture of Human Vestibular Schwannomas" @default.
- W4200321444 doi "https://doi.org/10.3791/51093-v" @default.
- W4200321444 hasPublicationYear "2014" @default.
- W4200321444 type Work @default.
- W4200321444 citedByCount "0" @default.
- W4200321444 crossrefType "journal-article" @default.
- W4200321444 hasAuthorship W4200321444A5012784574 @default.
- W4200321444 hasAuthorship W4200321444A5034747659 @default.
- W4200321444 hasAuthorship W4200321444A5075761198 @default.
- W4200321444 hasConcept C104317684 @default.
- W4200321444 hasConcept C127716648 @default.
- W4200321444 hasConcept C142724271 @default.
- W4200321444 hasConcept C15152581 @default.
- W4200321444 hasConcept C169760540 @default.
- W4200321444 hasConcept C190041318 @default.
- W4200321444 hasConcept C2778264664 @default.
- W4200321444 hasConcept C2778679214 @default.
- W4200321444 hasConcept C2778984943 @default.
- W4200321444 hasConcept C2781447767 @default.
- W4200321444 hasConcept C502942594 @default.
- W4200321444 hasConcept C54355233 @default.
- W4200321444 hasConcept C55493867 @default.
- W4200321444 hasConcept C555283112 @default.
- W4200321444 hasConcept C6045943 @default.
- W4200321444 hasConcept C71924100 @default.
- W4200321444 hasConcept C81885089 @default.
- W4200321444 hasConcept C86803240 @default.
- W4200321444 hasConceptScore W4200321444C104317684 @default.
- W4200321444 hasConceptScore W4200321444C127716648 @default.
- W4200321444 hasConceptScore W4200321444C142724271 @default.
- W4200321444 hasConceptScore W4200321444C15152581 @default.
- W4200321444 hasConceptScore W4200321444C169760540 @default.
- W4200321444 hasConceptScore W4200321444C190041318 @default.
- W4200321444 hasConceptScore W4200321444C2778264664 @default.
- W4200321444 hasConceptScore W4200321444C2778679214 @default.
- W4200321444 hasConceptScore W4200321444C2778984943 @default.
- W4200321444 hasConceptScore W4200321444C2781447767 @default.
- W4200321444 hasConceptScore W4200321444C502942594 @default.
- W4200321444 hasConceptScore W4200321444C54355233 @default.
- W4200321444 hasConceptScore W4200321444C55493867 @default.
- W4200321444 hasConceptScore W4200321444C555283112 @default.
- W4200321444 hasConceptScore W4200321444C6045943 @default.
- W4200321444 hasConceptScore W4200321444C71924100 @default.
- W4200321444 hasConceptScore W4200321444C81885089 @default.
- W4200321444 hasConceptScore W4200321444C86803240 @default.
- W4200321444 hasIssue "89" @default.
- W4200321444 hasLocation W42003214441 @default.
- W4200321444 hasOpenAccess W4200321444 @default.
- W4200321444 hasPrimaryLocation W42003214441 @default.
- W4200321444 hasRelatedWork W1608058689 @default.
- W4200321444 hasRelatedWork W1975222128 @default.
- W4200321444 hasRelatedWork W2026699360 @default.
- W4200321444 hasRelatedWork W2040013627 @default.
- W4200321444 hasRelatedWork W2146216414 @default.
- W4200321444 hasRelatedWork W2328686202 @default.
- W4200321444 hasRelatedWork W2373068004 @default.
- W4200321444 hasRelatedWork W2405693915 @default.
- W4200321444 hasRelatedWork W2898718478 @default.
- W4200321444 hasRelatedWork W3094834122 @default.
- W4200321444 isParatext "false" @default.
- W4200321444 isRetracted "false" @default.
- W4200321444 workType "article" @default.