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- W4200321851 abstract "Diabetes mellitus can be categorized into two major variants, type 1 and type 2. A number of traits such as clinical phenotype, age at disease onset, genetic background, and underlying pathogenesis distinguish the two forms.Recent evidence indicates that type 1 diabetes can be accompanied by insulin resistance and type 2 diabetes exhibits self-reactivity. These two previously unknown conditions can influence the progression and outcome of the disease. Unlike most conventional considerations, diabetes appears to consist of a spectrum of intermediate phenotypes that includes monogenic and polygenic loci linked to inflammatory processes including autoimmunity, beta cell impairment, and insulin resistance. Here we discuss why a shift of the classical bi-modal view of diabetes (autoimmune vs. non-autoimmune) is necessary in favor of a model of an immunological continuum of endotypes lying between the two extreme insulin-resistant and autoimmune beta cell targeting, shaped by environmental and genetic factors which contribute to determine specific immune-conditioned outcomes." @default.
- W4200321851 created "2021-12-31" @default.
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- W4200321851 date "2021-12-01" @default.
- W4200321851 modified "2023-10-17" @default.
- W4200321851 title "Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes" @default.
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- W4200321851 doi "https://doi.org/10.1007/s11892-021-01430-3" @default.
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