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• W4200322966 abstract "A common feature of both congenital and acquired forms of bone marrow failure is an increased risk of developing acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Indeed, the development of MDS or AML is now the major cause of mortality in patients with congenital neutropenia. Thus, there is a pressing clinical need to develop better strategies to prevent, diagnose early, and treat MDS/AML in patients with congenital neutropenia and other bone marrow failure syndromes. Here, we discuss recent data characterizing clonal hematopoiesis and progression to myeloid malignancy in congenital neutropenia, focusing on severe congenital neutropenia (SCN) and Shwachman-Diamond syndrome. We summarize recent studies showing excellent outcomes after allogenic hematopoietic stem cell transplantation for many (but not all) patients with congenital neutropenia, including patients with SCN with active myeloid malignancy who underwent transplantation. Finally, we discuss how these new data inform the current clinical management of patients with congenital neutropenia." @default.
• W4200322966 created "2021-12-31" @default.
• W4200322966 creator A5001246958 @default.
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• W4200322966 date "2021-12-10" @default.
• W4200322966 modified "2023-10-16" @default.
• W4200322966 title "Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis" @default.
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• W4200322966 doi "https://doi.org/10.1182/hematology.2021000286" @default.
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