Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200323492> ?p ?o ?g. }
- W4200323492 endingPage "74" @default.
- W4200323492 startingPage "74" @default.
- W4200323492 abstract "The early detection of bacterial pathogens through immune sensors is an essential step in innate immunity. STING (Stimulator of Interferon Genes) has emerged as a key mediator of inflammation in the setting of infection by connecting pathogen cytosolic recognition with immune responses. STING detects bacteria by directly recognizing cyclic dinucleotides or indirectly by bacterial genomic DNA sensing through the cyclic GMP-AMP synthase (cGAS). Upon activation, STING triggers a plethora of powerful signaling pathways, including the production of type I interferons and proinflammatory cytokines. STING activation has also been associated with the induction of endoplasmic reticulum (ER) stress and the associated inflammatory responses. Recent reports indicate that STING-dependent pathways participate in the metabolic reprogramming of macrophages and contribute to the establishment and maintenance of a robust inflammatory profile. The induction of this inflammatory state is typically antimicrobial and related to pathogen clearance. However, depending on the infection, STING-mediated immune responses can be detrimental to the host, facilitating bacterial survival, indicating an intricate balance between immune signaling and inflammation during bacterial infections. In this paper, we review recent insights regarding the role of STING in inducing an inflammatory profile upon intracellular bacterial entry in host cells and discuss the impact of STING signaling on the outcome of infection. Unraveling the STING-mediated inflammatory responses can enable a better understanding of the pathogenesis of certain bacterial diseases and reveal the potential of new antimicrobial therapy." @default.
- W4200323492 created "2021-12-31" @default.
- W4200323492 creator A5015444148 @default.
- W4200323492 creator A5071939546 @default.
- W4200323492 creator A5073910495 @default.
- W4200323492 creator A5074772430 @default.
- W4200323492 creator A5078687523 @default.
- W4200323492 date "2021-12-28" @default.
- W4200323492 modified "2023-10-16" @default.
- W4200323492 title "Impact of STING Inflammatory Signaling during Intracellular Bacterial Infections" @default.
- W4200323492 cites W1533182067 @default.
- W4200323492 cites W1544733216 @default.
- W4200323492 cites W1559117436 @default.
- W4200323492 cites W1593235986 @default.
- W4200323492 cites W1649667659 @default.
- W4200323492 cites W1804116733 @default.
- W4200323492 cites W1830488268 @default.
- W4200323492 cites W1940294549 @default.
- W4200323492 cites W1947117981 @default.
- W4200323492 cites W1947687476 @default.
- W4200323492 cites W1950462156 @default.
- W4200323492 cites W1957173764 @default.
- W4200323492 cites W1962869168 @default.
- W4200323492 cites W1973454407 @default.
- W4200323492 cites W1973720948 @default.
- W4200323492 cites W1978210814 @default.
- W4200323492 cites W1980923315 @default.
- W4200323492 cites W1984337734 @default.
- W4200323492 cites W1985563646 @default.
- W4200323492 cites W1987764697 @default.
- W4200323492 cites W1995878762 @default.
- W4200323492 cites W1998392642 @default.
- W4200323492 cites W2000177767 @default.
- W4200323492 cites W2002048532 @default.
- W4200323492 cites W2005852056 @default.
- W4200323492 cites W2009522156 @default.
- W4200323492 cites W2009716452 @default.
- W4200323492 cites W2012855647 @default.
- W4200323492 cites W2016131266 @default.
- W4200323492 cites W2018057790 @default.
- W4200323492 cites W2024296071 @default.
- W4200323492 cites W2024591203 @default.
- W4200323492 cites W2025268177 @default.
- W4200323492 cites W2028787589 @default.
- W4200323492 cites W2029607802 @default.
- W4200323492 cites W2035232303 @default.
- W4200323492 cites W2039390702 @default.
- W4200323492 cites W2039774779 @default.
- W4200323492 cites W2041345682 @default.
- W4200323492 cites W2047365750 @default.
- W4200323492 cites W2055063197 @default.
- W4200323492 cites W2057700117 @default.
- W4200323492 cites W2060004514 @default.
- W4200323492 cites W2065217848 @default.
- W4200323492 cites W2066818317 @default.
- W4200323492 cites W2071767667 @default.
- W4200323492 cites W2072510538 @default.
- W4200323492 cites W2081393349 @default.
- W4200323492 cites W2082889122 @default.
- W4200323492 cites W2089198803 @default.
- W4200323492 cites W2091180924 @default.
- W4200323492 cites W2097021177 @default.
- W4200323492 cites W2101141686 @default.
- W4200323492 cites W2108465046 @default.
- W4200323492 cites W2108961981 @default.
- W4200323492 cites W2109543073 @default.
- W4200323492 cites W2110456507 @default.
- W4200323492 cites W2110864354 @default.
- W4200323492 cites W2113757071 @default.
- W4200323492 cites W2114216755 @default.
- W4200323492 cites W2114257703 @default.
- W4200323492 cites W2118451644 @default.
- W4200323492 cites W2120736516 @default.
- W4200323492 cites W2122822209 @default.
- W4200323492 cites W2123440892 @default.
- W4200323492 cites W2131617804 @default.
- W4200323492 cites W2132393943 @default.
- W4200323492 cites W2135608359 @default.
- W4200323492 cites W2138453507 @default.
- W4200323492 cites W2139675947 @default.
- W4200323492 cites W2139848693 @default.
- W4200323492 cites W2149330714 @default.
- W4200323492 cites W2151684454 @default.
- W4200323492 cites W2155163967 @default.
- W4200323492 cites W2159560463 @default.
- W4200323492 cites W2167121345 @default.
- W4200323492 cites W2170002068 @default.
- W4200323492 cites W2237797200 @default.
- W4200323492 cites W2274936607 @default.
- W4200323492 cites W2310773425 @default.
- W4200323492 cites W2418688677 @default.
- W4200323492 cites W2461952548 @default.
- W4200323492 cites W2516449150 @default.
- W4200323492 cites W2531926556 @default.
- W4200323492 cites W2547204916 @default.
- W4200323492 cites W2553478620 @default.
- W4200323492 cites W2559769595 @default.
- W4200323492 cites W2561856169 @default.