Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200323722> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4200323722 endingPage "578" @default.
- W4200323722 startingPage "574" @default.
- W4200323722 abstract "Cisplatin (CP), an effective chemotherapeutic drug, has been widely used to treat the several types of tumors. Orientin (ORI) is a flavonoid that shows versatile therapeutic activities. The current research was planned to observe the protective role ORI on CP induced renal injury in rats. Twenty-four male rats were divided into four groups equally and termed as control, CP (10 mg/kg), CP (10 mg/kg) + ORI (40 mg/kg) and ORI (40 mg/kg). After seven days trial, rats were dissected and different parameters were analyzed. Results indicated that the CP administration significantly reduced the activities of catalase, peroxidase, glutathione reductase and glutathione content whereas it increased the level of hydrogen peroxide and TBARS (thiobarbituric acid reactive substances). CP increased the creatinine and urea levels while decreased the creatinine clearance. Moreover, CP significantly increased the inflammatory markers, including nuclear factor kappa-B, tumor necrosis factor-α, Interleukin-6, Interleukin-1β levels, cyclooxygenase-2 activity and histopathological damages. However, co-administration of ORI displayed curative effects against CP-induced renal toxicity and recovered all parameters by bringing them to a normal level. These results revealed that the ORI is a potential bioflavonoid that can potentially counter the CP-induced renal damage." @default.
- W4200323722 created "2021-12-31" @default.
- W4200323722 creator A5009488287 @default.
- W4200323722 date "2021-10-01" @default.
- W4200323722 modified "2023-09-30" @default.
- W4200323722 title "Orientin Attenuates Cisplatin-Induced Renal Toxicity by Reducing Oxidative Stress and Inflammation" @default.
- W4200323722 doi "https://doi.org/10.29261/pakvetj/2021.076" @default.
- W4200323722 hasPublicationYear "2021" @default.
- W4200323722 type Work @default.
- W4200323722 citedByCount "9" @default.
- W4200323722 countsByYear W42003237222022 @default.
- W4200323722 countsByYear W42003237222023 @default.
- W4200323722 crossrefType "journal-article" @default.
- W4200323722 hasAuthorship W4200323722A5009488287 @default.
- W4200323722 hasBestOaLocation W42003237221 @default.
- W4200323722 hasConcept C126189478 @default.
- W4200323722 hasConcept C126322002 @default.
- W4200323722 hasConcept C134018914 @default.
- W4200323722 hasConcept C159641895 @default.
- W4200323722 hasConcept C165069038 @default.
- W4200323722 hasConcept C181199279 @default.
- W4200323722 hasConcept C185592680 @default.
- W4200323722 hasConcept C2776151105 @default.
- W4200323722 hasConcept C2777352226 @default.
- W4200323722 hasConcept C2778760513 @default.
- W4200323722 hasConcept C2778979269 @default.
- W4200323722 hasConcept C2780306776 @default.
- W4200323722 hasConcept C2780829032 @default.
- W4200323722 hasConcept C29730261 @default.
- W4200323722 hasConcept C538909803 @default.
- W4200323722 hasConcept C55493867 @default.
- W4200323722 hasConcept C71924100 @default.
- W4200323722 hasConcept C98274493 @default.
- W4200323722 hasConceptScore W4200323722C126189478 @default.
- W4200323722 hasConceptScore W4200323722C126322002 @default.
- W4200323722 hasConceptScore W4200323722C134018914 @default.
- W4200323722 hasConceptScore W4200323722C159641895 @default.
- W4200323722 hasConceptScore W4200323722C165069038 @default.
- W4200323722 hasConceptScore W4200323722C181199279 @default.
- W4200323722 hasConceptScore W4200323722C185592680 @default.
- W4200323722 hasConceptScore W4200323722C2776151105 @default.
- W4200323722 hasConceptScore W4200323722C2777352226 @default.
- W4200323722 hasConceptScore W4200323722C2778760513 @default.
- W4200323722 hasConceptScore W4200323722C2778979269 @default.
- W4200323722 hasConceptScore W4200323722C2780306776 @default.
- W4200323722 hasConceptScore W4200323722C2780829032 @default.
- W4200323722 hasConceptScore W4200323722C29730261 @default.
- W4200323722 hasConceptScore W4200323722C538909803 @default.
- W4200323722 hasConceptScore W4200323722C55493867 @default.
- W4200323722 hasConceptScore W4200323722C71924100 @default.
- W4200323722 hasConceptScore W4200323722C98274493 @default.
- W4200323722 hasIssue "04" @default.
- W4200323722 hasLocation W42003237221 @default.
- W4200323722 hasOpenAccess W4200323722 @default.
- W4200323722 hasPrimaryLocation W42003237221 @default.
- W4200323722 hasRelatedWork W1969876840 @default.
- W4200323722 hasRelatedWork W1994790143 @default.
- W4200323722 hasRelatedWork W1995128157 @default.
- W4200323722 hasRelatedWork W2025081357 @default.
- W4200323722 hasRelatedWork W2133011674 @default.
- W4200323722 hasRelatedWork W2159964063 @default.
- W4200323722 hasRelatedWork W2181600100 @default.
- W4200323722 hasRelatedWork W2187603541 @default.
- W4200323722 hasRelatedWork W2462307694 @default.
- W4200323722 hasRelatedWork W2930721046 @default.
- W4200323722 hasVolume "41" @default.
- W4200323722 isParatext "false" @default.
- W4200323722 isRetracted "false" @default.
- W4200323722 workType "article" @default.