FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200324393> ?p ?o ?g. }

• W4200324393 abstract "Accumulating evidence indicates that high-fat diet (HFD) is a controllable risk factor for osteoporosis, but the underlying mechanism remains to be elucidated. As a primary biological barrier for nutrient entry into the human body, the composition and function of gut microbiota (GM) can be altered rapidly by HFD, which may trigger abnormal bone metabolism. In the current study, we analyzed the signatures of GM and serum metabolomics in HFD-induced bone loss and explored the potential correlations of GM and serum metabolites on HFD-related bone loss.We conducted a mouse model with HFD-induced bone loss through a 12-week diet intervention. Micro-CT, Osmium-μCT, and histological analyses were used to observe bone microstructure and bone marrow adipose tissue. Quantitative Real-Time PCR was applied to analyze gene expression related to osteogenesis, adipogenesis, and osteoclastogenesis. Enzyme-linked immunosorbent assay was used to measure the biochemical markers of bone turnover. 16s rDNA sequencing was employed to analyze the abundance of GM, and UHPLC-MS/MS was used to identify serum metabolites. Correlation analysis was performed to explore the relationships among bone phenotypes, GM, and the metabolome.HFD induced bone loss accompanied by bone marrow adipose tissue expansion and bone formation inhibition. In the HFD group, the relative abundance of Firmicutes was increased significantly, while Bacteroidetes, Actinobacteria, Epsilonbacteraeota, and Patescibacteria were decreased compared with the ND group. Association analysis showed that thirty-two bacterial genera were significantly related to bone volume per tissue volume (BV/TV). One hundred and forty-five serum metabolites were identified as differential metabolites associated with HFD intervention, which were significantly enriched in five pathways, such as purine metabolism, regulation of lipolysis in adipocyte and cGMP-PKG signaling pathway. Sixty-four diffiential metabolites were matched to the MS2 spectra; and ten of them were positively correlated with BV/TV and five were negatively correlated with BV/TV.These findings indicated that the alternations of GM and serum metabolites were related to HFD-induced bone loss, which might provide new insights into explain the occurrence and development of HFD-related osteoporosis. The regulatory effects of GM and metabolites associated with HFD on bone homeostasis required further exploration." @default.
• W4200324393 created "2021-12-31" @default.
• W4200324393 creator A5001193542 @default.
• W4200324393 creator A5013359711 @default.
• W4200324393 creator A5030694298 @default.
• W4200324393 creator A5032820605 @default.
• W4200324393 creator A5051884115 @default.
• W4200324393 creator A5063328758 @default.
• W4200324393 creator A5065989510 @default.
• W4200324393 creator A5071426386 @default.
• W4200324393 creator A5075311149 @default.
• W4200324393 date "2021-12-22" @default.
• W4200324393 modified "2023-10-16" @default.
• W4200324393 title "Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice" @default.
• W4200324393 cites W1501231953 @default.
• W4200324393 cites W1541472311 @default.
• W4200324393 cites W1795989887 @default.
• W4200324393 cites W1908000692 @default.
• W4200324393 cites W1977767980 @default.
• W4200324393 cites W1994703283 @default.
• W4200324393 cites W2006920340 @default.
• W4200324393 cites W2022331330 @default.
• W4200324393 cites W2037605343 @default.
• W4200324393 cites W2037869778 @default.
• W4200324393 cites W2049506766 @default.
• W4200324393 cites W2056279562 @default.
• W4200324393 cites W2065621427 @default.
• W4200324393 cites W2072952929 @default.
• W4200324393 cites W2076308137 @default.
• W4200324393 cites W2083698794 @default.
• W4200324393 cites W2085926377 @default.
• W4200324393 cites W2086865963 @default.
• W4200324393 cites W2088833470 @default.
• W4200324393 cites W2091922579 @default.
• W4200324393 cites W2100547925 @default.
• W4200324393 cites W2136879569 @default.
• W4200324393 cites W2139759128 @default.
• W4200324393 cites W2141677054 @default.
• W4200324393 cites W2152885278 @default.
• W4200324393 cites W2155544411 @default.
• W4200324393 cites W2163693480 @default.
• W4200324393 cites W2166562121 @default.
• W4200324393 cites W2170595651 @default.
• W4200324393 cites W2231561568 @default.
• W4200324393 cites W2343261030 @default.
• W4200324393 cites W2543113815 @default.
• W4200324393 cites W2559588208 @default.
• W4200324393 cites W2624855391 @default.
• W4200324393 cites W2767047143 @default.
• W4200324393 cites W2778082937 @default.
• W4200324393 cites W2794954240 @default.
• W4200324393 cites W2807951035 @default.
• W4200324393 cites W2886836648 @default.
• W4200324393 cites W2899811851 @default.
• W4200324393 cites W2900697674 @default.
• W4200324393 cites W2901990013 @default.
• W4200324393 cites W2914883768 @default.
• W4200324393 cites W2957498904 @default.
• W4200324393 cites W2980340201 @default.
• W4200324393 cites W2996402712 @default.
• W4200324393 cites W3025276666 @default.
• W4200324393 cites W3033559767 @default.
• W4200324393 cites W3034286391 @default.
• W4200324393 cites W3089396603 @default.
• W4200324393 cites W3091963223 @default.
• W4200324393 cites W3096743526 @default.
• W4200324393 cites W3102422239 @default.
• W4200324393 cites W3107159126 @default.
• W4200324393 cites W3113296208 @default.
• W4200324393 cites W3127989306 @default.
• W4200324393 cites W3133165021 @default.
• W4200324393 cites W3135670207 @default.
• W4200324393 cites W3138110822 @default.
• W4200324393 cites W3139465266 @default.
• W4200324393 cites W3155896569 @default.
• W4200324393 cites W3158973719 @default.
• W4200324393 cites W3159003956 @default.
• W4200324393 cites W3167014587 @default.
• W4200324393 cites W3183496115 @default.
• W4200324393 cites W3195967056 @default.
• W4200324393 cites W91108901 @default.
• W4200324393 doi "https://doi.org/10.3389/fcimb.2021.788576" @default.
• W4200324393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35004355" @default.
• W4200324393 hasPublicationYear "2021" @default.
• W4200324393 type Work @default.
• W4200324393 citedByCount "15" @default.
• W4200324393 countsByYear W42003243932022 @default.
• W4200324393 countsByYear W42003243932023 @default.
• W4200324393 crossrefType "journal-article" @default.
• W4200324393 hasAuthorship W4200324393A5001193542 @default.
• W4200324393 hasAuthorship W4200324393A5013359711 @default.
• W4200324393 hasAuthorship W4200324393A5030694298 @default.
• W4200324393 hasAuthorship W4200324393A5032820605 @default.
• W4200324393 hasAuthorship W4200324393A5051884115 @default.
• W4200324393 hasAuthorship W4200324393A5063328758 @default.
• W4200324393 hasAuthorship W4200324393A5065989510 @default.
• W4200324393 hasAuthorship W4200324393A5071426386 @default.
• W4200324393 hasAuthorship W4200324393A5075311149 @default.
• W4200324393 hasBestOaLocation W42003243931 @default.
• W4200324393 hasConcept C104317684 @default.

• next