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- W4200324817 abstract "Inhibitory neurons innervating the perisomatic region of cortical excitatory principal cells are known to control the emergence of several physiological and pathological synchronous events, including epileptic interictal spikes. In humans, little is known about their role in synchrony generation, although their changes in epilepsy have been thoroughly investigated. This paper demonstraits how parvalbumin (PV)- and type 1 cannabinoid receptor (CB1R)-positive perisomatic interneurons innervate pyramidal cell bodies, and their role in synchronous population events spontaneously emerging in the human epileptic and non-epileptic neocortex, in vitro. Quantitative electron microscopy showed that the overall, PV+ and CB1R+ somatic inhibitory inputs remained unchanged in focal cortical epilepsy. On the contrary, the size of PV-stained synapses increased, and their number decreased in epileptic samples, in synchrony generating regions. Pharmacology demonstrated-in conjunction with the electron microscopy-that although both perisomatic cell types participate, PV+ cells have stronger influence on the generation of population activity in epileptic samples. The somatic inhibitory input of neocortical pyramidal cells remained almost intact in epilepsy, but the larger and consequently more efficient somatic synapses might account for a higher synchrony in this neuron population. This, together with epileptic hyperexcitability, might make a cortical region predisposed to generate or participate in hypersynchronous events." @default.
- W4200324817 created "2021-12-31" @default.
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- W4200324817 date "2021-12-24" @default.
- W4200324817 modified "2023-10-16" @default.
- W4200324817 title "Perisomatic Inhibition and Its Relation to Epilepsy and to Synchrony Generation in the Human Neocortex" @default.
- W4200324817 cites W1482435409 @default.
- W4200324817 cites W1531931383 @default.
- W4200324817 cites W1547160898 @default.
- W4200324817 cites W1567718628 @default.
- W4200324817 cites W1589155811 @default.
- W4200324817 cites W1592286181 @default.
- W4200324817 cites W1602463275 @default.
- W4200324817 cites W1631495829 @default.
- W4200324817 cites W1965486572 @default.
- W4200324817 cites W1970931021 @default.
- W4200324817 cites W1976291966 @default.
- W4200324817 cites W1977679473 @default.
- W4200324817 cites W1979486221 @default.
- W4200324817 cites W1983529828 @default.
- W4200324817 cites W1989356891 @default.
- W4200324817 cites W1989398878 @default.
- W4200324817 cites W1993938369 @default.
- W4200324817 cites W1996444783 @default.
- W4200324817 cites W1998848813 @default.
- W4200324817 cites W2001611710 @default.
- W4200324817 cites W2008027377 @default.
- W4200324817 cites W2009069766 @default.
- W4200324817 cites W2009332732 @default.
- W4200324817 cites W2013185877 @default.
- W4200324817 cites W2013575848 @default.
- W4200324817 cites W2015952034 @default.
- W4200324817 cites W2021401120 @default.
- W4200324817 cites W2023221517 @default.
- W4200324817 cites W2029393114 @default.
- W4200324817 cites W2032774941 @default.
- W4200324817 cites W2036640239 @default.
- W4200324817 cites W2038328684 @default.
- W4200324817 cites W2040159169 @default.
- W4200324817 cites W2040930687 @default.
- W4200324817 cites W2042962532 @default.
- W4200324817 cites W2050022483 @default.
- W4200324817 cites W2052809998 @default.
- W4200324817 cites W2054926428 @default.
- W4200324817 cites W2055938779 @default.
- W4200324817 cites W2059504616 @default.
- W4200324817 cites W2060589548 @default.
- W4200324817 cites W2062776921 @default.
- W4200324817 cites W2064685631 @default.
- W4200324817 cites W2065834998 @default.
- W4200324817 cites W2069650489 @default.
- W4200324817 cites W2074484764 @default.
- W4200324817 cites W2075514099 @default.
- W4200324817 cites W2077847569 @default.
- W4200324817 cites W2080086613 @default.
- W4200324817 cites W2082233643 @default.
- W4200324817 cites W2084402322 @default.
- W4200324817 cites W2086818286 @default.
- W4200324817 cites W2087291581 @default.
- W4200324817 cites W2088081549 @default.
- W4200324817 cites W2093514926 @default.
- W4200324817 cites W2099046443 @default.
- W4200324817 cites W2099878623 @default.
- W4200324817 cites W2100438317 @default.
- W4200324817 cites W2101608461 @default.
- W4200324817 cites W2103322364 @default.
- W4200324817 cites W2104474697 @default.
- W4200324817 cites W2110519400 @default.
- W4200324817 cites W2113960469 @default.
- W4200324817 cites W2115460562 @default.
- W4200324817 cites W2124545724 @default.
- W4200324817 cites W2126766019 @default.
- W4200324817 cites W2132383929 @default.
- W4200324817 cites W2143998666 @default.
- W4200324817 cites W2145617691 @default.
- W4200324817 cites W2147028194 @default.
- W4200324817 cites W2150497419 @default.
- W4200324817 cites W2157338202 @default.
- W4200324817 cites W2161088063 @default.
- W4200324817 cites W2166751395 @default.
- W4200324817 cites W2170038102 @default.
- W4200324817 cites W2195685976 @default.
- W4200324817 cites W2294653186 @default.
- W4200324817 cites W2323795706 @default.
- W4200324817 cites W2551177094 @default.
- W4200324817 cites W2552726820 @default.