Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200325087> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4200325087 abstract "Aims: This study aimed to develop a high-performance liquid chromatography (HPLC) technique for estimating paracetamol glucuronide and paracetamol sulphate in the urine samples of preterm neonates. Background: Validated methods exist for estimating the principal metabolites of paracetamol in older children and those with liver disease. Here, we have developed and validated a simple technique for estimating the same in urine samples of preterm neonates. Objective: The study aims to develop and validate a simple, reliable, and accurate HPLC technique for estimating urinary paracetamol glucuronide and paracetamol sulphate metabolites. Methods: Preterm neonates of either sex diagnosed with patent ductus arteriosus (PDA) receiving paracetamol intravenously at the dose of 15 mg/kg every six hours were recruited. We ran the samples under standardized chromatographic conditions and using various dilutions of the calibration standards. Measures of assay selectivity, linearity, accuracy, and precision were estimated. Results: We observed that the peaks for paracetamol glucuronide and paracetamol sulphate were distinguished from those of the drug-free urine samples. The results for both metabolites revealed good reproducibility, with a percent coefficient of variation (% CV) of 4.3 and 4.9 for the slope for paracetamol glucuronide and paracetamol sulphate, respectively. Similarly, we observed good linearity, as indicated by the correlation coefficients of 0.99 for the metabolites. The validation assays revealed that the method is linear, accurate, and precise over the defined concentration ranges. Conclusion: We demonstrated that HPLC has good accuracy, reliability, and precision, and it can be used for estimating the principal metabolites from urine samples in neonates for defining the ontogeny of conjugation enzymes and in paracetamol overdose." @default.
- W4200325087 created "2021-12-31" @default.
- W4200325087 creator A5020721733 @default.
- W4200325087 creator A5023891140 @default.
- W4200325087 date "2022-03-01" @default.
- W4200325087 modified "2023-10-01" @default.
- W4200325087 title "Development of Urinary Assay Methods for the Estimation of Paracetamol Glucuronide and Paracetamol Sulphate in Preterm Neonates with Patent Ductus Arteriosus" @default.
- W4200325087 cites W1967750041 @default.
- W4200325087 cites W1972097194 @default.
- W4200325087 cites W1972321236 @default.
- W4200325087 cites W1978895902 @default.
- W4200325087 cites W1986014229 @default.
- W4200325087 cites W1995420466 @default.
- W4200325087 cites W2023879230 @default.
- W4200325087 cites W2036971200 @default.
- W4200325087 cites W2058791176 @default.
- W4200325087 cites W2079724543 @default.
- W4200325087 cites W2096265199 @default.
- W4200325087 cites W2157726429 @default.
- W4200325087 cites W2587812355 @default.
- W4200325087 cites W2978602195 @default.
- W4200325087 cites W3131660257 @default.
- W4200325087 cites W4238724023 @default.
- W4200325087 doi "https://doi.org/10.2174/2213240608666211202092036" @default.
- W4200325087 hasPublicationYear "2022" @default.
- W4200325087 type Work @default.
- W4200325087 citedByCount "2" @default.
- W4200325087 countsByYear W42003250872022 @default.
- W4200325087 countsByYear W42003250872023 @default.
- W4200325087 crossrefType "journal-article" @default.
- W4200325087 hasAuthorship W4200325087A5020721733 @default.
- W4200325087 hasAuthorship W4200325087A5023891140 @default.
- W4200325087 hasConcept C126322002 @default.
- W4200325087 hasConcept C179998833 @default.
- W4200325087 hasConcept C185592680 @default.
- W4200325087 hasConcept C2778722691 @default.
- W4200325087 hasConcept C2779186261 @default.
- W4200325087 hasConcept C2780026642 @default.
- W4200325087 hasConcept C2781236024 @default.
- W4200325087 hasConcept C43617362 @default.
- W4200325087 hasConcept C71924100 @default.
- W4200325087 hasConcept C77411442 @default.
- W4200325087 hasConcept C89838059 @default.
- W4200325087 hasConcept C98274493 @default.
- W4200325087 hasConcept C9893847 @default.
- W4200325087 hasConceptScore W4200325087C126322002 @default.
- W4200325087 hasConceptScore W4200325087C179998833 @default.
- W4200325087 hasConceptScore W4200325087C185592680 @default.
- W4200325087 hasConceptScore W4200325087C2778722691 @default.
- W4200325087 hasConceptScore W4200325087C2779186261 @default.
- W4200325087 hasConceptScore W4200325087C2780026642 @default.
- W4200325087 hasConceptScore W4200325087C2781236024 @default.
- W4200325087 hasConceptScore W4200325087C43617362 @default.
- W4200325087 hasConceptScore W4200325087C71924100 @default.
- W4200325087 hasConceptScore W4200325087C77411442 @default.
- W4200325087 hasConceptScore W4200325087C89838059 @default.
- W4200325087 hasConceptScore W4200325087C98274493 @default.
- W4200325087 hasConceptScore W4200325087C9893847 @default.
- W4200325087 hasFunder F4320311396 @default.
- W4200325087 hasIssue "1" @default.
- W4200325087 hasLocation W42003250871 @default.
- W4200325087 hasOpenAccess W4200325087 @default.
- W4200325087 hasPrimaryLocation W42003250871 @default.
- W4200325087 hasRelatedWork W1871281899 @default.
- W4200325087 hasRelatedWork W1985896768 @default.
- W4200325087 hasRelatedWork W2008587079 @default.
- W4200325087 hasRelatedWork W2008727242 @default.
- W4200325087 hasRelatedWork W2012905376 @default.
- W4200325087 hasRelatedWork W2042816791 @default.
- W4200325087 hasRelatedWork W2053210750 @default.
- W4200325087 hasRelatedWork W2078718962 @default.
- W4200325087 hasRelatedWork W2132222874 @default.
- W4200325087 hasRelatedWork W2377120588 @default.
- W4200325087 hasVolume "9" @default.
- W4200325087 isParatext "false" @default.
- W4200325087 isRetracted "false" @default.
- W4200325087 workType "article" @default.