FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200325128> ?p ?o ?g. }

• W4200325128 abstract "Background Although the expression of RNA-binding protein (RBP) genes in hepatocellular carcinoma (HCC) varies and is associated with tumor progression, there has been no overview study with multiple cohorts and large samples. The HCC-associated RBP genes need to be more accurately identified, and their clinical application value needs to be further explored. Methods First, we used the robust rank aggregation (RRA) algorithm to extract HCC-associated RBP genes from nine HCC microarray datasets and verified them in The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) cohort and International Cancer Genome Consortium (ICGC) Japanese liver cancer (ICGC-LIRI-JP) cohort. In addition, the copy number variation (CNV), single-nucleotide variant (SNV), and promoter-region methylation data of HCC-associated RBP genes were analyzed. Using the random forest algorithm, we constructed an RBP gene–based prognostic score system (RBP-score). We then evaluated the ability of RBP-score to predict the prognosis of patients. The relationships between RBP-score and other clinical characteristics of patients were analyzed. Results The RRA algorithm identified 30 RBP mRNAs with consistent expression patterns across the nine HCC microarray datasets. These 30 RBP genes were defined as HCC-associated RBP genes. Their mRNA expression patterns were further verified in the TCGA-LIHC and ICGC-LIRI-JP cohorts. Among these 30 RBP genes, some showed significant copy number gain or loss, while others showed differences in the methylation levels of their promoter regions. Some RBP genes were risk factors or protective factors for the prognosis of patients. We extracted 10 key HCC-associated RBP genes using the random forest algorithm and constructed an RBP-score system. RBP-score effectively predicted the overall survival (OS) and disease-free survival (DFS) of HCC patients and was associated with the tumor, node, metastasis (TNM) stage, α-fetoprotein (AFP), and metastasis risk. The clinical value of RBP-score was validated in datasets from different platforms. Cox analysis suggested that a high RBP-score was an independent risk factor for poor prognosis in HCC patients. We also successfully established a combined RBP-score+TNM LASSO-Cox model that more accurately predicted the prognosis. Conclusion The RBP-score system constructed based on HCC-associated RBP genes is a simple and highly effective prognostic evaluation tool. It is suitable for different subgroups of HCC patients and has cross-platform characteristics. Combining RBP-score with the TNM staging system or other clinical parameters can lead to an even greater clinical benefit. In addition, the identified HCC-associated RBP genes may serve as novel targets for HCC treatment." @default.
• W4200325128 created "2021-12-31" @default.
• W4200325128 date "2021-12-20" @default.
• W4200325128 modified "2023-09-28" @default.
• W4200325128 title "Supplemental Information 11: Information for datasets used in the present study." @default.
• W4200325128 doi "https://doi.org/10.7717/peerj.12572/supp-11" @default.
• W4200325128 hasPublicationYear "2021" @default.
• W4200325128 type Work @default.
• W4200325128 citedByCount "0" @default.
• W4200325128 crossrefType "component" @default.
• W4200325128 hasBestOaLocation W42003251281 @default.
• W4200325128 hasConcept C104317684 @default.
• W4200325128 hasConcept C120821319 @default.
• W4200325128 hasConcept C126322002 @default.
• W4200325128 hasConcept C141231307 @default.
• W4200325128 hasConcept C143998085 @default.
• W4200325128 hasConcept C150194340 @default.
• W4200325128 hasConcept C186836561 @default.
• W4200325128 hasConcept C2776231280 @default.
• W4200325128 hasConcept C2778019345 @default.
• W4200325128 hasConcept C33288867 @default.
• W4200325128 hasConcept C502942594 @default.
• W4200325128 hasConcept C54355233 @default.
• W4200325128 hasConcept C71924100 @default.
• W4200325128 hasConcept C72563966 @default.
• W4200325128 hasConcept C8415881 @default.
• W4200325128 hasConcept C86803240 @default.
• W4200325128 hasConceptScore W4200325128C104317684 @default.
• W4200325128 hasConceptScore W4200325128C120821319 @default.
• W4200325128 hasConceptScore W4200325128C126322002 @default.
• W4200325128 hasConceptScore W4200325128C141231307 @default.
• W4200325128 hasConceptScore W4200325128C143998085 @default.
• W4200325128 hasConceptScore W4200325128C150194340 @default.
• W4200325128 hasConceptScore W4200325128C186836561 @default.
• W4200325128 hasConceptScore W4200325128C2776231280 @default.
• W4200325128 hasConceptScore W4200325128C2778019345 @default.
• W4200325128 hasConceptScore W4200325128C33288867 @default.
• W4200325128 hasConceptScore W4200325128C502942594 @default.
• W4200325128 hasConceptScore W4200325128C54355233 @default.
• W4200325128 hasConceptScore W4200325128C71924100 @default.
• W4200325128 hasConceptScore W4200325128C72563966 @default.
• W4200325128 hasConceptScore W4200325128C8415881 @default.
• W4200325128 hasConceptScore W4200325128C86803240 @default.
• W4200325128 hasLocation W42003251281 @default.
• W4200325128 hasOpenAccess W4200325128 @default.
• W4200325128 hasPrimaryLocation W42003251281 @default.
• W4200325128 hasRelatedWork W1193901 @default.
• W4200325128 hasRelatedWork W12125326 @default.
• W4200325128 hasRelatedWork W14401804 @default.
• W4200325128 hasRelatedWork W17416549 @default.
• W4200325128 hasRelatedWork W18386857 @default.
• W4200325128 hasRelatedWork W2282960 @default.
• W4200325128 hasRelatedWork W3830736 @default.
• W4200325128 hasRelatedWork W4312996 @default.
• W4200325128 hasRelatedWork W517575 @default.
• W4200325128 hasRelatedWork W6294011 @default.
• W4200325128 isParatext "false" @default.
• W4200325128 isRetracted "false" @default.
• W4200325128 workType "paratext" @default.