Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200326310> ?p ?o ?g. }
- W4200326310 abstract "The intestine has many types of cells that are present mostly in the epithelium and lamina propria. The importance of the intestinal cells for the mammalian mucosal immune system is well-established. However, there is no in-depth information about many of the intestinal cells in teleosts. In our previous study, we reported that adherent intestinal cells (AIC) predominantly express macrophage-related genes. To gather further evidence that AIC include macrophage-like cells, we compared their phagocytic activity and morphology with those of adherent head kidney cells (AKC), previously characterized as macrophage-like cells. We also compared equally abundant as well as differentially expressed mRNAs and miRNAs between AIC and AKC. AIC had lower phagocytic activity and were larger and more circular than macrophage-like AKC. RNA-Seq data revealed that there were 18309 mRNAs, with 59 miRNAs that were equally abundant between AIC and AKC. Integrative analysis of the mRNA and miRNA transcriptomes revealed macrophage heterogeneity in both AIC and AKC. In addition, analysis of AIC and AKC transcriptomes revealed functional characteristics of mucosal and systemic macrophages. Five pairs with significant negative correlations between miRNA and mRNAs were linked to macrophages and epithelial cells and their interaction could be pointing to macrophage activation and differentiation. The potential macrophage markers suggested in this study should be investigated under different immune conditions to understand the exact macrophage phenotypes." @default.
- W4200326310 created "2021-12-31" @default.
- W4200326310 creator A5008535260 @default.
- W4200326310 creator A5010647454 @default.
- W4200326310 creator A5031227823 @default.
- W4200326310 creator A5071878346 @default.
- W4200326310 creator A5077321852 @default.
- W4200326310 date "2021-12-23" @default.
- W4200326310 modified "2023-09-23" @default.
- W4200326310 title "Macrophage Heterogeneity in the Intestinal Cells of Salmon: Hints From Transcriptomic and Imaging Data" @default.
- W4200326310 cites W1484605038 @default.
- W4200326310 cites W1596482914 @default.
- W4200326310 cites W1898713645 @default.
- W4200326310 cites W1927296860 @default.
- W4200326310 cites W1944858750 @default.
- W4200326310 cites W1973433801 @default.
- W4200326310 cites W1974783503 @default.
- W4200326310 cites W1982205229 @default.
- W4200326310 cites W1988827679 @default.
- W4200326310 cites W1991112668 @default.
- W4200326310 cites W1991160853 @default.
- W4200326310 cites W2014946489 @default.
- W4200326310 cites W2015031635 @default.
- W4200326310 cites W2018217649 @default.
- W4200326310 cites W2019279852 @default.
- W4200326310 cites W2021794852 @default.
- W4200326310 cites W2035618305 @default.
- W4200326310 cites W2036897871 @default.
- W4200326310 cites W2038180405 @default.
- W4200326310 cites W2049218066 @default.
- W4200326310 cites W2052758686 @default.
- W4200326310 cites W2062094117 @default.
- W4200326310 cites W2062502136 @default.
- W4200326310 cites W2067003464 @default.
- W4200326310 cites W2070571588 @default.
- W4200326310 cites W2071113403 @default.
- W4200326310 cites W2074751666 @default.
- W4200326310 cites W2075037899 @default.
- W4200326310 cites W2087417324 @default.
- W4200326310 cites W2105172891 @default.
- W4200326310 cites W2106616076 @default.
- W4200326310 cites W2115048931 @default.
- W4200326310 cites W2116136455 @default.
- W4200326310 cites W2120456037 @default.
- W4200326310 cites W2124756133 @default.
- W4200326310 cites W2130305733 @default.
- W4200326310 cites W2145189896 @default.
- W4200326310 cites W2147291647 @default.
- W4200326310 cites W2151114382 @default.
- W4200326310 cites W2151935175 @default.
- W4200326310 cites W2153406260 @default.
- W4200326310 cites W2154085311 @default.
- W4200326310 cites W2163716193 @default.
- W4200326310 cites W2169456326 @default.
- W4200326310 cites W2169843232 @default.
- W4200326310 cites W2179438025 @default.
- W4200326310 cites W2191880222 @default.
- W4200326310 cites W2265978074 @default.
- W4200326310 cites W2302022292 @default.
- W4200326310 cites W2347100538 @default.
- W4200326310 cites W2408996547 @default.
- W4200326310 cites W2521783763 @default.
- W4200326310 cites W2541610918 @default.
- W4200326310 cites W2570381783 @default.
- W4200326310 cites W2572195256 @default.
- W4200326310 cites W2589216136 @default.
- W4200326310 cites W2606267500 @default.
- W4200326310 cites W2732456683 @default.
- W4200326310 cites W2738882047 @default.
- W4200326310 cites W2751743884 @default.
- W4200326310 cites W2768173964 @default.
- W4200326310 cites W2781139158 @default.
- W4200326310 cites W2789342460 @default.
- W4200326310 cites W2810741265 @default.
- W4200326310 cites W2897197322 @default.
- W4200326310 cites W2897751115 @default.
- W4200326310 cites W2901305534 @default.
- W4200326310 cites W2901410689 @default.
- W4200326310 cites W2903513810 @default.
- W4200326310 cites W2904076340 @default.
- W4200326310 cites W2904801293 @default.
- W4200326310 cites W2910603257 @default.
- W4200326310 cites W2919579975 @default.
- W4200326310 cites W2935952674 @default.
- W4200326310 cites W2940899024 @default.
- W4200326310 cites W2945702356 @default.
- W4200326310 cites W2955150470 @default.
- W4200326310 cites W2963656050 @default.
- W4200326310 cites W2968055772 @default.
- W4200326310 cites W3007163612 @default.
- W4200326310 cites W3008761072 @default.
- W4200326310 cites W3013801226 @default.
- W4200326310 cites W3015623817 @default.
- W4200326310 cites W3017894821 @default.
- W4200326310 cites W3033828598 @default.
- W4200326310 cites W3037617531 @default.
- W4200326310 cites W3048076282 @default.
- W4200326310 cites W3092669394 @default.
- W4200326310 cites W3093065104 @default.
- W4200326310 cites W3098355877 @default.