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• W4200326475 abstract "In this issue of Atherosclerosis, Sharma et al. present an interesting study on the association of sex hormones with the prevalence and progression of extra-coronary calcium (ECC) [ [1] Sharma A. Ogunmoroti O. Fashanu O.E. et al. Associations of Endogenous Sex Hormone Levels with the Prevalence and Progression of Valvular and Thoracic Aortic Calcification in the Multi-Ethnic Study of Atherosclerosis (MESA) Atherosclerosis. 2021 Abstract Full Text Full Text PDF Scopus (1) Google Scholar ]. The authors studied 5867 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective multi-center study exploring subclinical atherosclerosis in US adults aged 45–85 without clinical cardiovascular disease (CVD) at baseline. The cohort consisted of 2737 post-menopausal women and 3130 men with endogenous sex hormone levels measured at baseline, and ECG-gated cardiac computed tomography scans done at baseline and follow-up. Free testosterone (free T) and sex-hormone-binding globulin (SHBG) (per 1-standard deviation increase) were used and the main outcome was the presence and extent of ECC, inclusive of thoracic aortic calcification (ascending (ATAC) and descending (DTAC)) and left-sided valvular calcifications (mitral annular calcification (MAC) and aortic valve calcification (AVC)). All analyses were segregated by sex. The prevalence of ATAC/DTAC/MAC/AVC was 4% | 34% | 13% | 12% and 4% | 26% | 8% | 17% among women and men, respectively. In men, higher SHBG and lower free T were associated with prevalence and extent of MAC after adjusting for several baseline covariates. In women, lower SHBG was found to be associated with extent of AVC and MAC in models adjusted for demographic factors, but this association was no longer significant in maximally adjusted models. After a mean follow-up of 2.4 years, incident ATAC/DTAC/MAC/AVC were 2% | 15% | 4% | 6% in women and 2% | 11% | 5% | 4% in men. In men, higher SHBG and lower free T were significantly associated with the incidence and progression of DTAC in multivariable-adjusted models. A similar observation was seen with incident MAC in women, but only in models adjusted for sociodemographic factors. Results were similar in a sensitivity analysis excluding women currently on hormone therapy." @default.
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• W4200326475 date "2021-12-01" @default.
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• W4200326475 title "Extra cardiac calcification: A new round in the battle of the sex (hormones)" @default.
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• W4200326475 doi "https://doi.org/10.1016/j.atherosclerosis.2021.12.010" @default.
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