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- W4200326719 abstract "Abstract Developmental control of jaw size is crucial to prevent disease and facilitate evolution. We have shown that species-specific differences in jaw size are established by neural crest mesenchyme (NCM), which are the jaw progenitors that migrate into the mandibular primordia. NCM relies on multiple signaling molecules including Sonic Hedgehog (SHH) to mediate interactions with mandibular epithelium that facilitate outgrowth of the jaws. SHH signaling is known to promote outgrowth and so we tested if differential regulation of the SHH pathway can account for species-specific variation in mandibular primordia size. We analyze gene expression of SHH pathway members in duck, chick, and quail, and find higher transcriptional activation in the larger mandibular primordia of duck relative to those of chick and quail. We generate quail-duck chimeras and demonstrate that such activation is NCM-mediated. Gain- and loss-of-function experiments reveal a species-specific response to SHH signaling, with the target Gas1 being most sensitive to manipulations. Gas1 overexpression and knockdown in NCM alters cell number and/or mandibular primordia size. Our work suggests that NCM-mediated changes in SHH signaling may modulate jaw size during development, disease, and evolution. Summary Statement We have determined that Gas1 , which is a component of the SHH signaling pathway, plays a key role in the development and evolution of jaw size." @default.
- W4200326719 created "2021-12-31" @default.
- W4200326719 creator A5001011973 @default.
- W4200326719 creator A5034186664 @default.
- W4200326719 creator A5065246526 @default.
- W4200326719 creator A5067463039 @default.
- W4200326719 creator A5069253305 @default.
- W4200326719 date "2021-12-18" @default.
- W4200326719 modified "2023-09-27" @default.
- W4200326719 title "Differential regulation of SHH signaling and the developmental control of species-specific jaw size through neural crest-mediated Gas1 expression" @default.
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