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- W4200326770 abstract "Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of brain-derived fibrils of the mouse anchorless RML scrapie strain which, like the recently determined hamster 263K strain, has a parallel in-register β-sheet-based core. However, detailed comparisons reveal that variations in shared structural motifs provide a basis for prion strain determination. One-sentence summary Cryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences." @default.
- W4200326770 created "2021-12-31" @default.
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- W4200326770 date "2021-12-22" @default.
- W4200326770 modified "2023-10-18" @default.
- W4200326770 title "Structure of anchorless RML prion reveals motif variation between strains" @default.
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- W4200326770 doi "https://doi.org/10.1101/2021.12.22.473909" @default.
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