Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200328757> ?p ?o ?g. }
- W4200328757 abstract "MicroRNAs, small non-coding RNA molecules with about 22 nucleotides in length, play a significant role in the development of bladder cancer. Previous studies found that miR-616-5p could promote the progress of cancers. However, its role in bladder cancer remains unclear. In the study, we aimed to demonstrate how miR-616-5p impacts the invasion and migration of bladder cancer and its potential downstream targets.Firstly, qRT-PCR was used to detect the expression of miR-616-5p in normal bladder uroepithelial cell lines and bladder cancer cell lines. Then, chamber-transwell invasion and wound healing migration assays were used to detect the roles of miR-616-5p and NR2C2 in invasion and migration. Subsequently, Western blot was used to evaluate the regulation effects of miR-616-5p and NR2C2. Finally, luciferase assays were performed to manifest the mechanism of miR-616-5p and NR2C2 regulation.We found that miR-616-5p was upregulated in bladder cancer, and it could promote the invasion and migration of bladder cancer in vitro. Moreover, we demonstrated that NR2C2 was a downstream target of miR-616-5p. miR-616-5p could inhibit the expression of NR2C2 by binding to the 3'UTR of NR2C2 mRNA. Importantly, patients with a high expression of NR2C2 showed better prognoses in bladder cancer.This study identifies that miR-616-5p can promote bladder cancer progression via altering the expression of NR2C2. Therefore, identifying miR-616-5p expression levels might be a useful strategy for developing potential therapeutic targets in bladder cancer." @default.
- W4200328757 created "2021-12-31" @default.
- W4200328757 creator A5017763246 @default.
- W4200328757 creator A5032902658 @default.
- W4200328757 creator A5040894219 @default.
- W4200328757 creator A5049299709 @default.
- W4200328757 creator A5056410986 @default.
- W4200328757 creator A5069542455 @default.
- W4200328757 creator A5091034237 @default.
- W4200328757 date "2021-12-09" @default.
- W4200328757 modified "2023-10-10" @default.
- W4200328757 title "miR-616-5p Promotes Invasion and Migration of Bladder Cancer via Downregulating NR2C2 Expression" @default.
- W4200328757 cites W144423133 @default.
- W4200328757 cites W1804201762 @default.
- W4200328757 cites W1996445359 @default.
- W4200328757 cites W2002995168 @default.
- W4200328757 cites W2008160952 @default.
- W4200328757 cites W2014946489 @default.
- W4200328757 cites W2016360721 @default.
- W4200328757 cites W2042679193 @default.
- W4200328757 cites W2058044693 @default.
- W4200328757 cites W2103257412 @default.
- W4200328757 cites W2124756133 @default.
- W4200328757 cites W2153381450 @default.
- W4200328757 cites W2167467342 @default.
- W4200328757 cites W2309801891 @default.
- W4200328757 cites W2473162054 @default.
- W4200328757 cites W2558131410 @default.
- W4200328757 cites W2597632520 @default.
- W4200328757 cites W2604517301 @default.
- W4200328757 cites W2741518739 @default.
- W4200328757 cites W2767377392 @default.
- W4200328757 cites W2790210103 @default.
- W4200328757 cites W2797611703 @default.
- W4200328757 cites W2810980477 @default.
- W4200328757 cites W2889646458 @default.
- W4200328757 cites W2946657092 @default.
- W4200328757 cites W2955825265 @default.
- W4200328757 cites W2969983122 @default.
- W4200328757 cites W2987680479 @default.
- W4200328757 cites W3017948648 @default.
- W4200328757 cites W3023288864 @default.
- W4200328757 cites W3045949537 @default.
- W4200328757 cites W3047040253 @default.
- W4200328757 cites W3131264924 @default.
- W4200328757 cites W3139511935 @default.
- W4200328757 cites W3141462199 @default.
- W4200328757 cites W3146565636 @default.
- W4200328757 cites W3191779913 @default.
- W4200328757 cites W4211053712 @default.
- W4200328757 doi "https://doi.org/10.3389/fonc.2021.762946" @default.
- W4200328757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34956884" @default.
- W4200328757 hasPublicationYear "2021" @default.
- W4200328757 type Work @default.
- W4200328757 citedByCount "6" @default.
- W4200328757 countsByYear W42003287572023 @default.
- W4200328757 crossrefType "journal-article" @default.
- W4200328757 hasAuthorship W4200328757A5017763246 @default.
- W4200328757 hasAuthorship W4200328757A5032902658 @default.
- W4200328757 hasAuthorship W4200328757A5040894219 @default.
- W4200328757 hasAuthorship W4200328757A5049299709 @default.
- W4200328757 hasAuthorship W4200328757A5056410986 @default.
- W4200328757 hasAuthorship W4200328757A5069542455 @default.
- W4200328757 hasAuthorship W4200328757A5091034237 @default.
- W4200328757 hasBestOaLocation W42003287571 @default.
- W4200328757 hasConcept C104317684 @default.
- W4200328757 hasConcept C105580179 @default.
- W4200328757 hasConcept C121608353 @default.
- W4200328757 hasConcept C126322002 @default.
- W4200328757 hasConcept C127561419 @default.
- W4200328757 hasConcept C137738243 @default.
- W4200328757 hasConcept C143998085 @default.
- W4200328757 hasConcept C145059251 @default.
- W4200328757 hasConcept C1491633281 @default.
- W4200328757 hasConcept C2776415932 @default.
- W4200328757 hasConcept C2780352672 @default.
- W4200328757 hasConcept C502942594 @default.
- W4200328757 hasConcept C54355233 @default.
- W4200328757 hasConcept C55493867 @default.
- W4200328757 hasConcept C71924100 @default.
- W4200328757 hasConcept C86803240 @default.
- W4200328757 hasConceptScore W4200328757C104317684 @default.
- W4200328757 hasConceptScore W4200328757C105580179 @default.
- W4200328757 hasConceptScore W4200328757C121608353 @default.
- W4200328757 hasConceptScore W4200328757C126322002 @default.
- W4200328757 hasConceptScore W4200328757C127561419 @default.
- W4200328757 hasConceptScore W4200328757C137738243 @default.
- W4200328757 hasConceptScore W4200328757C143998085 @default.
- W4200328757 hasConceptScore W4200328757C145059251 @default.
- W4200328757 hasConceptScore W4200328757C1491633281 @default.
- W4200328757 hasConceptScore W4200328757C2776415932 @default.
- W4200328757 hasConceptScore W4200328757C2780352672 @default.
- W4200328757 hasConceptScore W4200328757C502942594 @default.
- W4200328757 hasConceptScore W4200328757C54355233 @default.
- W4200328757 hasConceptScore W4200328757C55493867 @default.
- W4200328757 hasConceptScore W4200328757C71924100 @default.
- W4200328757 hasConceptScore W4200328757C86803240 @default.
- W4200328757 hasFunder F4320321001 @default.
- W4200328757 hasFunder F4320322843 @default.
- W4200328757 hasLocation W42003287571 @default.