Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200329168> ?p ?o ?g. }
- W4200329168 endingPage "2557" @default.
- W4200329168 startingPage "2548" @default.
- W4200329168 abstract "Biliverdin IXβ reductase B (BLVRB) has recently been proposed as a novel therapeutic target for thrombocytopenia through its reactive oxygen species (ROS)-associated mechanism. Thus, we aim at repurposing drugs as new inhibitors of BLVRB. Based on IC50 (<5 μM), we have identified 20 compounds out of 1496 compounds from the Food and Drug Administration (FDA)-approved library and have clearly mapped their binding sites to the active site. Furthermore, we show the detailed BLVRB-binding modes and thermodynamic properties (ΔH, ΔS, and KD) with nuclear magnetic resonance (NMR) and isothermal titration calorimetry together with complex structures of eight water-soluble compounds. We anticipate that the results will serve as a novel platform for further in-depth studies on BLVRB effects for related functions such as ROS accumulation and megakaryocyte differentiation, and ultimately treatments of platelet disorders." @default.
- W4200329168 created "2021-12-31" @default.
- W4200329168 creator A5005333819 @default.
- W4200329168 creator A5015072505 @default.
- W4200329168 creator A5019838849 @default.
- W4200329168 creator A5034326355 @default.
- W4200329168 creator A5037375841 @default.
- W4200329168 creator A5044839728 @default.
- W4200329168 creator A5062468404 @default.
- W4200329168 creator A5068049306 @default.
- W4200329168 creator A5073284312 @default.
- W4200329168 creator A5078652028 @default.
- W4200329168 creator A5081039263 @default.
- W4200329168 creator A5087013596 @default.
- W4200329168 date "2021-12-27" @default.
- W4200329168 modified "2023-10-16" @default.
- W4200329168 title "Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IXβ Reductase B as a Novel Thrombocytopenia Therapeutic Target" @default.
- W4200329168 cites W1031578623 @default.
- W4200329168 cites W1539796472 @default.
- W4200329168 cites W1738956265 @default.
- W4200329168 cites W1787801016 @default.
- W4200329168 cites W1963187716 @default.
- W4200329168 cites W1964729357 @default.
- W4200329168 cites W1968217711 @default.
- W4200329168 cites W1976161355 @default.
- W4200329168 cites W1976499671 @default.
- W4200329168 cites W1981225934 @default.
- W4200329168 cites W1987777210 @default.
- W4200329168 cites W1990866919 @default.
- W4200329168 cites W1997106161 @default.
- W4200329168 cites W2006016016 @default.
- W4200329168 cites W2012473810 @default.
- W4200329168 cites W2021801189 @default.
- W4200329168 cites W2023921624 @default.
- W4200329168 cites W2033428105 @default.
- W4200329168 cites W2035687084 @default.
- W4200329168 cites W2036056642 @default.
- W4200329168 cites W2036864051 @default.
- W4200329168 cites W2044894228 @default.
- W4200329168 cites W2054979333 @default.
- W4200329168 cites W2059398341 @default.
- W4200329168 cites W2062344864 @default.
- W4200329168 cites W2062941476 @default.
- W4200329168 cites W2067174909 @default.
- W4200329168 cites W2068788903 @default.
- W4200329168 cites W2070403068 @default.
- W4200329168 cites W2080847612 @default.
- W4200329168 cites W2081311414 @default.
- W4200329168 cites W2081693079 @default.
- W4200329168 cites W2081976853 @default.
- W4200329168 cites W2103317372 @default.
- W4200329168 cites W2124026197 @default.
- W4200329168 cites W2126649678 @default.
- W4200329168 cites W2128572087 @default.
- W4200329168 cites W2132629607 @default.
- W4200329168 cites W2135796724 @default.
- W4200329168 cites W2144288821 @default.
- W4200329168 cites W2147993766 @default.
- W4200329168 cites W2150650800 @default.
- W4200329168 cites W2157566126 @default.
- W4200329168 cites W2161605421 @default.
- W4200329168 cites W2170928666 @default.
- W4200329168 cites W2180229411 @default.
- W4200329168 cites W2266013672 @default.
- W4200329168 cites W2307253401 @default.
- W4200329168 cites W2330510515 @default.
- W4200329168 cites W2332896222 @default.
- W4200329168 cites W2394732186 @default.
- W4200329168 cites W2460479900 @default.
- W4200329168 cites W2558789531 @default.
- W4200329168 cites W2755935192 @default.
- W4200329168 cites W2788933792 @default.
- W4200329168 cites W2809039065 @default.
- W4200329168 cites W2885573217 @default.
- W4200329168 cites W2901470592 @default.
- W4200329168 cites W2947409936 @default.
- W4200329168 cites W2947633746 @default.
- W4200329168 cites W2969623581 @default.
- W4200329168 cites W3013953493 @default.
- W4200329168 cites W4240910312 @default.
- W4200329168 cites W4253049361 @default.
- W4200329168 cites W4317523919 @default.
- W4200329168 doi "https://doi.org/10.1021/acs.jmedchem.1c01664" @default.
- W4200329168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34957824" @default.
- W4200329168 hasPublicationYear "2021" @default.
- W4200329168 type Work @default.
- W4200329168 citedByCount "1" @default.
- W4200329168 countsByYear W42003291682023 @default.
- W4200329168 crossrefType "journal-article" @default.
- W4200329168 hasAuthorship W4200329168A5005333819 @default.
- W4200329168 hasAuthorship W4200329168A5015072505 @default.
- W4200329168 hasAuthorship W4200329168A5019838849 @default.
- W4200329168 hasAuthorship W4200329168A5034326355 @default.
- W4200329168 hasAuthorship W4200329168A5037375841 @default.
- W4200329168 hasAuthorship W4200329168A5044839728 @default.
- W4200329168 hasAuthorship W4200329168A5062468404 @default.
- W4200329168 hasAuthorship W4200329168A5068049306 @default.
- W4200329168 hasAuthorship W4200329168A5073284312 @default.