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• W4200330414 endingPage "1454" @default.
• W4200330414 startingPage "1454" @default.
• W4200330414 abstract "Ischemic and traumatic insults to the central nervous system account for most serious acute and fatal brain injuries and are usually characterized by primary and secondary damage. Secondary damage presents the greatest challenge for medical staff; however, there are currently few effective therapeutic targets for secondary damage. Homer proteins are postsynaptic scaffolding proteins that have been implicated in ischemic and traumatic insults to the central nervous system. Homer signaling can exert either positive or negative effects during such insults, depending on the specific subtype of Homer protein. Homer 1b/c couples with other proteins to form postsynaptic densities, which form the basis of synaptic transmission, while Homer1a expression can be induced by harmful external factors. Homer 1c is used as a unique biomarker to reveal alterations in synaptic connectivity before and during the early stages of apoptosis in retinal ganglion cells, mediated or affected by extracellular or intracellular signaling or cytoskeletal processes. This review summarizes the structural features, related signaling pathways, and diverse roles of Homer proteins in physiological and pathological processes. Upregulating Homer1a or downregulating Homer1b/c may play a neuroprotective role in secondary brain injuries. Homer also plays an important role in the formation of photoreceptor synapses. These findings confirm the neuroprotective effects of Homer, and support the future design of therapeutic drug targets or gene therapies for ischemic and traumatic brain injuries and retinal disorders based on Homer proteins." @default.
• W4200330414 created "2021-12-31" @default.
• W4200330414 creator A5014455930 @default.
• W4200330414 creator A5029708895 @default.
• W4200330414 creator A5070027201 @default.
• W4200330414 date "2022-01-01" @default.
• W4200330414 modified "2023-09-27" @default.
• W4200330414 title "Homer signaling pathways as effective therapeutic targets for ischemic and traumatic brain injuries and retinal lesions" @default.
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• W4200330414 doi "https://doi.org/10.4103/1673-5374.330588" @default.

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