Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200335036> ?p ?o ?g. }
- W4200335036 endingPage "128185" @default.
- W4200335036 startingPage "128185" @default.
- W4200335036 abstract "In any skin wound, the wound bed present on vitalized tissues serves as a reservoir for bacterial growth. Nanoscaffolds modified with amine functional groups due to their ability to interact with the cellular structure, is a promising alternative to combat the controversies faced with existing wound closure methods. The present study deals with the design and fabrication of electrospun amine-functionalized SBA-15 (Santa Barbara Amorphous) incorporated with PVA (Poly Vinyl Alcohol) and Curcumin, a plant-derived phytochemical compound, known for its anti-microbial, anti-inflammatory and skin wound healing properties. Amine functionalized SBA-15 with its high porosity and biocompatible characteristics enhance the solubility of the hydrophobic drug Curcumin, further aiding its release in a controlled manner. SEM images of nanofibrous scaffolds depicts the highly interconnected fibers with porous structure bio-mimicking the Extra Cellular Matrix (ECM). Results of antibacterial activity against the gram-negative Escherichia coli and gram-positive Bacillus subtilis exhibits a distinct zone of inhibition. Cell migration, cell proliferation, and biocompatibility of the prepared nanoscaffold is investigated through MTT assay, cell adhesion assay and live dead assay using Swiss 3T6 cells. Amine functionalized SBA-15 incorporated PVA nanofibrous scaffolds exhibits enhanced in vitro cyto-compatibility. Bio-compatibility studies investigated through in vivo analysis using female Wistar rats reveal 98% of wound contraction with scar-less wound healing for the amine-functionalized SBA-15 incorporated nanoscaffolds within 18 days. Results of histopathology analysis through Hematoxylin-Eosin and Masson’s tri-chrome staining confirm re-epithelization of tissue, formation of granulation tissue and collagen. Thus, the PVA/NH2-SBA-15(5%)/Cur nanofibrous scaffold with positive charge interacts with negative charge on the cellular surface exhibiting enhanced cell adhesion and proliferation which further accelerates the wound healing process." @default.
- W4200335036 created "2021-12-31" @default.
- W4200335036 creator A5002999396 @default.
- W4200335036 creator A5004215562 @default.
- W4200335036 creator A5054202991 @default.
- W4200335036 creator A5080859533 @default.
- W4200335036 date "2022-03-01" @default.
- W4200335036 modified "2023-10-18" @default.
- W4200335036 title "Synthesis and fabrication of amine functionalized SBA-15 incorporated PVA/Curcumin nanofiber for skin wound healing application" @default.
- W4200335036 cites W1203351676 @default.
- W4200335036 cites W1524119749 @default.
- W4200335036 cites W1538151922 @default.
- W4200335036 cites W1538936148 @default.
- W4200335036 cites W1810511947 @default.
- W4200335036 cites W1972315718 @default.
- W4200335036 cites W1976886475 @default.
- W4200335036 cites W1982202108 @default.
- W4200335036 cites W1991422616 @default.
- W4200335036 cites W1993244611 @default.
- W4200335036 cites W1998815241 @default.
- W4200335036 cites W2001766762 @default.
- W4200335036 cites W2022675670 @default.
- W4200335036 cites W2023676540 @default.
- W4200335036 cites W2025418345 @default.
- W4200335036 cites W2031822535 @default.
- W4200335036 cites W2035923893 @default.
- W4200335036 cites W2038449324 @default.
- W4200335036 cites W2038836811 @default.
- W4200335036 cites W2052465295 @default.
- W4200335036 cites W2055775372 @default.
- W4200335036 cites W2056611743 @default.
- W4200335036 cites W2071928197 @default.
- W4200335036 cites W2076337862 @default.
- W4200335036 cites W2079958908 @default.
- W4200335036 cites W2084058449 @default.
- W4200335036 cites W2085605828 @default.
- W4200335036 cites W2085720812 @default.
- W4200335036 cites W2085928781 @default.
- W4200335036 cites W2087976016 @default.
- W4200335036 cites W2092204511 @default.
- W4200335036 cites W2102618395 @default.
- W4200335036 cites W2104145556 @default.
- W4200335036 cites W2114918609 @default.
- W4200335036 cites W2124865710 @default.
- W4200335036 cites W2136510151 @default.
- W4200335036 cites W2163352718 @default.
- W4200335036 cites W2176588479 @default.
- W4200335036 cites W2236998776 @default.
- W4200335036 cites W2252265855 @default.
- W4200335036 cites W2269056964 @default.
- W4200335036 cites W2519459731 @default.
- W4200335036 cites W2548516545 @default.
- W4200335036 cites W2554032260 @default.
- W4200335036 cites W2557843841 @default.
- W4200335036 cites W2577047016 @default.
- W4200335036 cites W2580079359 @default.
- W4200335036 cites W2605678043 @default.
- W4200335036 cites W2618137169 @default.
- W4200335036 cites W2622263840 @default.
- W4200335036 cites W2742964677 @default.
- W4200335036 cites W2752586739 @default.
- W4200335036 cites W2754671563 @default.
- W4200335036 cites W2763173066 @default.
- W4200335036 cites W2767893554 @default.
- W4200335036 cites W2773056536 @default.
- W4200335036 cites W2774336772 @default.
- W4200335036 cites W2775388813 @default.
- W4200335036 cites W2779386460 @default.
- W4200335036 cites W2783615925 @default.
- W4200335036 cites W2810958914 @default.
- W4200335036 cites W2885333067 @default.
- W4200335036 cites W2885814196 @default.
- W4200335036 cites W2890376362 @default.
- W4200335036 cites W2892828376 @default.
- W4200335036 cites W2896108941 @default.
- W4200335036 cites W2899439097 @default.
- W4200335036 cites W2900125153 @default.
- W4200335036 cites W2904407793 @default.
- W4200335036 cites W2907671680 @default.
- W4200335036 cites W2909505539 @default.
- W4200335036 cites W2911400448 @default.
- W4200335036 cites W2914402909 @default.
- W4200335036 cites W2914651089 @default.
- W4200335036 cites W2944056866 @default.
- W4200335036 cites W2944121442 @default.
- W4200335036 cites W2947240275 @default.
- W4200335036 cites W2947570776 @default.
- W4200335036 cites W2948955420 @default.
- W4200335036 cites W2956132477 @default.
- W4200335036 cites W2958352310 @default.
- W4200335036 cites W2975857343 @default.
- W4200335036 cites W2978715266 @default.
- W4200335036 cites W2981806447 @default.
- W4200335036 cites W2996208379 @default.
- W4200335036 cites W2997345121 @default.
- W4200335036 cites W3000704961 @default.
- W4200335036 cites W3003210281 @default.
- W4200335036 cites W3013414850 @default.