FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200337546> ?p ?o ?g. }

• W4200337546 endingPage "101669" @default.
• W4200337546 startingPage "101669" @default.
• W4200337546 abstract "The mechanism that mediates L-citrulline (L-Cit) hypothermia is poorly understood, and the involvement of nitric oxide signaling has not been fully elucidated. Therefore, this study aimed to determine L-Cit's influence on body temperature and to ascertain the central and peripheral mechanisms associated with this response. Chicks responded to intracerebroventricular (ICV) injection of L-Cit with high and low body temperatures (P < 0.05) depending on the dose tested, for both the surface and rectal temperatures. Peripheral (i.p.) L-Cit injection did not affect body temperature responses. Nitric oxide (NO) concentration and NO synthase (NOS) were influenced with varying doses of L-Cit. Hypothalamic NO was increased at 4 µg L-Cit whereas, plasma iNOS was elevated at 2µg L-Cit treatment. However, i.p. L-Cit did not change the NO content, rather it induced higher (P < 0.05) plasma tNOS and iNOS activity, and further upregulated iNOS and nNOS gene expression in the hypothalamus. In addition, ICV L-Cit potentiated a pro- versus anti-inflammatory milieu with the induction of IL-8, IL-10, and TGFβ (P < 0.05), which may be related to the changes in body temperature. Following ICV L-Cit administration, it was observed that L-Cit caused dose variable changes in the ultrastructure of hypothalamic neurons. The lowest dose was associated with a higher number of dead or degenerating neurons, whereas the highest L-Cit dose had fewer neuronal numbers with larger sizes. Therefore, this study shows that central and peripheral L-Cit administration imposes changes in body temperature, nitric oxide production, and inflammatory responses, in a dose-dependent manner." @default.
• W4200337546 created "2021-12-31" @default.
• W4200337546 creator A5007924062 @default.
• W4200337546 creator A5011135963 @default.
• W4200337546 creator A5020147975 @default.
• W4200337546 creator A5068902273 @default.
• W4200337546 creator A5069120331 @default.
• W4200337546 creator A5088228460 @default.
• W4200337546 date "2022-03-01" @default.
• W4200337546 modified "2023-10-17" @default.
• W4200337546 title "Central and peripheral effects of L-citrulline on thermal physiology and nitric oxide regeneration in broilers" @default.
• W4200337546 cites W1150974541 @default.
• W4200337546 cites W1549497398 @default.
• W4200337546 cites W1563565728 @default.
• W4200337546 cites W1584106444 @default.
• W4200337546 cites W1835820473 @default.
• W4200337546 cites W1856201115 @default.
• W4200337546 cites W1975698396 @default.
• W4200337546 cites W1977045526 @default.
• W4200337546 cites W1977063479 @default.
• W4200337546 cites W1980591250 @default.
• W4200337546 cites W1995214617 @default.
• W4200337546 cites W1999866182 @default.
• W4200337546 cites W2007209721 @default.
• W4200337546 cites W2009310709 @default.
• W4200337546 cites W2019249909 @default.
• W4200337546 cites W2026183163 @default.
• W4200337546 cites W2026788098 @default.
• W4200337546 cites W2034922192 @default.
• W4200337546 cites W2051386121 @default.
• W4200337546 cites W2052948496 @default.
• W4200337546 cites W2053085373 @default.
• W4200337546 cites W2054082563 @default.
• W4200337546 cites W2058486417 @default.
• W4200337546 cites W2060414535 @default.
• W4200337546 cites W2066014655 @default.
• W4200337546 cites W2066427182 @default.
• W4200337546 cites W2066586960 @default.
• W4200337546 cites W2068642085 @default.
• W4200337546 cites W2073743068 @default.
• W4200337546 cites W2111445243 @default.
• W4200337546 cites W2118848360 @default.
• W4200337546 cites W2122057284 @default.
• W4200337546 cites W2147222575 @default.
• W4200337546 cites W2162463567 @default.
• W4200337546 cites W2167835953 @default.
• W4200337546 cites W2215738169 @default.
• W4200337546 cites W2277796992 @default.
• W4200337546 cites W2551092627 @default.
• W4200337546 cites W2604132026 @default.
• W4200337546 cites W2736692870 @default.
• W4200337546 cites W2760256497 @default.
• W4200337546 cites W2765776267 @default.
• W4200337546 cites W2771458856 @default.
• W4200337546 cites W2801930959 @default.
• W4200337546 cites W2803758722 @default.
• W4200337546 cites W2902087076 @default.
• W4200337546 cites W2904681937 @default.
• W4200337546 cites W2914213505 @default.
• W4200337546 cites W2944823669 @default.
• W4200337546 cites W3012231563 @default.
• W4200337546 cites W3017282398 @default.
• W4200337546 cites W3092188811 @default.
• W4200337546 cites W3122676327 @default.
• W4200337546 cites W3191520866 @default.
• W4200337546 cites W750395963 @default.
• W4200337546 cites W107174068 @default.
• W4200337546 doi "https://doi.org/10.1016/j.psj.2021.101669" @default.
• W4200337546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35101686" @default.
• W4200337546 hasPublicationYear "2022" @default.
• W4200337546 type Work @default.
• W4200337546 citedByCount "4" @default.
• W4200337546 countsByYear W42003375462022 @default.
• W4200337546 countsByYear W42003375462023 @default.
• W4200337546 crossrefType "journal-article" @default.
• W4200337546 hasAuthorship W4200337546A5007924062 @default.
• W4200337546 hasAuthorship W4200337546A5011135963 @default.
• W4200337546 hasAuthorship W4200337546A5020147975 @default.
• W4200337546 hasAuthorship W4200337546A5068902273 @default.
• W4200337546 hasAuthorship W4200337546A5069120331 @default.
• W4200337546 hasAuthorship W4200337546A5088228460 @default.
• W4200337546 hasBestOaLocation W42003375461 @default.
• W4200337546 hasConcept C100564792 @default.
• W4200337546 hasConcept C126322002 @default.
• W4200337546 hasConcept C134018914 @default.
• W4200337546 hasConcept C185592680 @default.
• W4200337546 hasConcept C2777003273 @default.
• W4200337546 hasConcept C2777468819 @default.
• W4200337546 hasConcept C2777622882 @default.
• W4200337546 hasConcept C2779129087 @default.
• W4200337546 hasConcept C46762472 @default.
• W4200337546 hasConcept C515207424 @default.
• W4200337546 hasConcept C519581460 @default.
• W4200337546 hasConcept C55493867 @default.
• W4200337546 hasConcept C71924100 @default.
• W4200337546 hasConcept C86803240 @default.
• W4200337546 hasConceptScore W4200337546C100564792 @default.
• W4200337546 hasConceptScore W4200337546C126322002 @default.

• next