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• W4200339743 startingPage "76" @default.
• W4200339743 abstract "The lymph node plays a critical role in mounting an adaptive immune response to infection, clearance of foreign pathogens, and cancer immunosurveillance. Within this complex structure, intranodal migration is vital for CD8+ T cell activation and differentiation. Combining tissue clearing and volumetric light sheet fluorescent microscopy of intact lymph nodes has allowed us to explore the spatial regulation of T cell fates. This has determined that short-lived effector (TSLEC ) are imprinted in peripheral lymph node interfollicular regions, due to CXCR3 migration. In contrast, stem-like memory cell (TSCM ) differentiation is determined in the T cell paracortex. Here, we detail the inflammatory and chemokine regulators of spatially restricted T cell differentiation, with a focus on how to promote TSCM . We propose a default pathway for TSCM differentiation due to CCR7-directed segregation of precursors away from the inflammatory effector niche. Although volumetric imaging has revealed the consequences of intranodal migration, we still lack knowledge of how this is orchestrated within a complex chemokine environment. Toward this goal, we highlight the potential of combining microfluidic chambers with pre-determined complexity and subcellular resolution microscopy." @default.
• W4200339743 created "2021-12-31" @default.
• W4200339743 creator A5030092965 @default.
• W4200339743 creator A5046363867 @default.
• W4200339743 creator A5078448235 @default.
• W4200339743 date "2021-12-09" @default.
• W4200339743 modified "2023-10-08" @default.
• W4200339743 title "Spatial determinates of effector and memory CD8 ⁺ T cell fates*" @default.
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