Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200340324> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4200340324 endingPage "639" @default.
- W4200340324 startingPage "628" @default.
- W4200340324 abstract "Glabridin, a bioactive compound that originally isolated from the roots of licorice (Glycyrrhiza glabra L., Fam. Fabaceae), has a wide range of pharmacological properties for instance anti-inflammatory, anti-cancer, anti-microbial, anti-viral, anti-osteoporosis, anti-diabetic, anti-atherogenic, neuroprotective, estrogenic, and skin-whitening. Even though, biological activities and pharmacological properties of glabridin have already been determined, molecular signaling pathways, gene targets, and pharmacological properties based on bioinformatics analyses have not been fully elucidated. Thus, in the presented research, network-based bioinformatics approaches were applied to demonstrate targets of glabridin in human genomes and proteomes. The glabridin was input into the ChEBI database, and the targets of its were predicted using DIGEP-Pred, and then, top interacting genes were identified by GeneCards database. Afterward, STRING and KEGG enrichment database were used to construct a protein-protein interaction (PPI) network and molecular targeting pathway network, respectively. A total of 14 genes coding proteins such as UGT1A1, MAPK1, CYP2B6, MMP9, CHKA, CYP3A4, EGFR, PON1, SLC6A4, SRC, EPHX2, TYR, PTK2, and PPIG effected by glabridin were determined by gene set enrichment analysis. Furthermore, multiple pathways including endocrine resistance, bladder cancer, ErbB signaling pathway, VEGF signaling pathway, chemical carcinogenesis, proteoglycans in cancer, relaxin signaling pathway, and estrogen signaling pathway were also identified to be regulated by glabridin. This research showed that glabridin exhibits highly active pharmacological activity as an anti-infective agent, chemopreventive agent, membrane permeability inhibitor, melanin inhibitor, and apoptosis agonist. Taken together, this study is network-based scientific research that will be very useful in elucidating the biological, molecular and pharmacological properties of glabridin for clinical applications in detail." @default.
- W4200340324 created "2021-12-31" @default.
- W4200340324 creator A5007121645 @default.
- W4200340324 creator A5052142908 @default.
- W4200340324 date "2021-12-15" @default.
- W4200340324 modified "2023-10-06" @default.
- W4200340324 title "Bioinformatics analyses on molecular pathways and pharmacological properties of Glabridin" @default.
- W4200340324 cites W184793361 @default.
- W4200340324 cites W1935434993 @default.
- W4200340324 cites W1959511032 @default.
- W4200340324 cites W1969891004 @default.
- W4200340324 cites W1979942274 @default.
- W4200340324 cites W1992135143 @default.
- W4200340324 cites W2010768245 @default.
- W4200340324 cites W2032360583 @default.
- W4200340324 cites W2036864615 @default.
- W4200340324 cites W2059271652 @default.
- W4200340324 cites W2059765353 @default.
- W4200340324 cites W2129853470 @default.
- W4200340324 cites W2206751118 @default.
- W4200340324 cites W2335512083 @default.
- W4200340324 cites W2559588208 @default.
- W4200340324 cites W2582372140 @default.
- W4200340324 cites W2803070016 @default.
- W4200340324 cites W2909946668 @default.
- W4200340324 cites W2922755946 @default.
- W4200340324 cites W2969939418 @default.
- W4200340324 cites W3015204302 @default.
- W4200340324 cites W3025295102 @default.
- W4200340324 cites W3089201336 @default.
- W4200340324 cites W3108924497 @default.
- W4200340324 cites W3108948778 @default.
- W4200340324 cites W3126552923 @default.
- W4200340324 cites W3185891471 @default.
- W4200340324 doi "https://doi.org/10.31015/jaefs.2021.4.23" @default.
- W4200340324 hasPublicationYear "2021" @default.
- W4200340324 type Work @default.
- W4200340324 citedByCount "0" @default.
- W4200340324 crossrefType "journal-article" @default.
- W4200340324 hasAuthorship W4200340324A5007121645 @default.
- W4200340324 hasAuthorship W4200340324A5052142908 @default.
- W4200340324 hasBestOaLocation W42003403241 @default.
- W4200340324 hasConcept C104317684 @default.
- W4200340324 hasConcept C150194340 @default.
- W4200340324 hasConcept C152724338 @default.
- W4200340324 hasConcept C162317418 @default.
- W4200340324 hasConcept C185592680 @default.
- W4200340324 hasConcept C55493867 @default.
- W4200340324 hasConcept C62478195 @default.
- W4200340324 hasConcept C86803240 @default.
- W4200340324 hasConcept C98274493 @default.
- W4200340324 hasConcept C9927688 @default.
- W4200340324 hasConceptScore W4200340324C104317684 @default.
- W4200340324 hasConceptScore W4200340324C150194340 @default.
- W4200340324 hasConceptScore W4200340324C152724338 @default.
- W4200340324 hasConceptScore W4200340324C162317418 @default.
- W4200340324 hasConceptScore W4200340324C185592680 @default.
- W4200340324 hasConceptScore W4200340324C55493867 @default.
- W4200340324 hasConceptScore W4200340324C62478195 @default.
- W4200340324 hasConceptScore W4200340324C86803240 @default.
- W4200340324 hasConceptScore W4200340324C98274493 @default.
- W4200340324 hasConceptScore W4200340324C9927688 @default.
- W4200340324 hasIssue "4" @default.
- W4200340324 hasLocation W42003403241 @default.
- W4200340324 hasOpenAccess W4200340324 @default.
- W4200340324 hasPrimaryLocation W42003403241 @default.
- W4200340324 hasRelatedWork W1993710246 @default.
- W4200340324 hasRelatedWork W1998927743 @default.
- W4200340324 hasRelatedWork W2892268684 @default.
- W4200340324 hasRelatedWork W3040179460 @default.
- W4200340324 hasRelatedWork W3203549747 @default.
- W4200340324 hasRelatedWork W4200225397 @default.
- W4200340324 hasRelatedWork W4210617599 @default.
- W4200340324 hasRelatedWork W4232902031 @default.
- W4200340324 hasRelatedWork W4252582945 @default.
- W4200340324 hasRelatedWork W4366597364 @default.
- W4200340324 hasVolume "5" @default.
- W4200340324 isParatext "false" @default.
- W4200340324 isRetracted "false" @default.
- W4200340324 workType "article" @default.