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• W4200340960 abstract "The modification of proteins by O-linked β- N -acetylglucosamine (O-GlcNAc) is associated with the regulation of numerous cellular processes. Despite the importance of O-GlcNAc in mediating cellular function our understanding of the mechanisms that regulate O-GlcNAc levels is limited. One factor known to regulate protein O-GlcNAc levels is nutrient availability; however, the fact that nutrient deficient states such as ischemia increase O-GlcNAc levels suggests that other factors also contribute to regulating O-GlcNAc levels. We have previously reported that in unstressed cardiomyocytes exogenous NAD + resulted in a time and dose dependent decrease in O-GlcNAc levels. Therefore, we postulated that NAD + and cellular O-GlcNAc levels may be coordinately regulated. Using glucose deprivation as a model system in an immortalized human ventricular cell line, we examined the influence of extracellular NAD + on cellular O-GlcNAc levels and ER stress in the presence and absence of glucose. We found that NAD + completely blocked the increase in O-GlcNAc induced by glucose deprivation and suppressed the activation of ER stress. The NAD + metabolite cyclic ADP-ribose (cADPR) had similar effects on O-GlcNAc and ER stress suggesting a common underlying mechanism. cADPR is a ryanodine receptor (RyR) agonist and like caffeine, which also activates the RyR, both mimicked the effects of NAD + . SERCA inhibition, which also reduces ER/SR Ca 2+ levels had similar effects to both NAD + and cADPR on O-GlcNAc and ER stress responses to glucose deprivation. The observation that NAD + , cADPR, and caffeine all attenuated the increase in O-GlcNAc and ER stress in response to glucose deprivation, suggests a potential common mechanism, linked to ER/SR Ca 2+ levels, underlying their activation. Moreover, we showed that TRPM2, a plasma membrane cation channel was necessary for the cellular responses to glucose deprivation. Collectively, these findings support a novel Ca 2+ -dependent mechanism underlying glucose deprivation induced increase in O-GlcNAc and ER stress." @default.
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• W4200340960 date "2021-12-07" @default.
• W4200340960 modified "2023-10-15" @default.
• W4200340960 title "The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress" @default.
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• W4200340960 doi "https://doi.org/10.3389/fmolb.2021.780865" @default.
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