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- W4200343207 abstract "Mouse hepatitis virus (MHV; m-β-CoV) serves as a useful model for studying the cellular factors involved in neuroinflammation. To understand the role of matrix metalloproteinases (MMPs) in neuroinflammation, brain tissues from m-β-CoV-infected mice were harvested at different days post-infection (d.p.i) and investigated for Mmp expression by RT-qPCR. Mmp-2, -3, -8, -12 showed significant mRNA upregulation peaking with viral replication between 5 and 6 d.p.i. Elevated levels of MMP regulator TIMP-1 are suggestive of a TIMP-1 mediated host antiviral response. Biological network assessment suggested a direct involvement of MMP-3, -8, -14 in facilitating peripheral leukocyte infiltrations. Flow cytometry confirmed the increased presence of NK cells, CD4+ and CD8+ T cells, neutrophils, and MHCII expressing cells in the m-β-CoV infected mice brain. Our study revealed that m-β-CoV upregulated Park7, RelA, Nrf2, and Hmox1 transcripts involved in ROS production and antioxidant pathways, describing the possible nexus between oxidative pathways, MMPs, and TIMP in m-β-CoV-induced neuroinflammation." @default.
- W4200343207 created "2021-12-31" @default.
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- W4200343207 date "2022-01-01" @default.
- W4200343207 modified "2023-10-17" @default.
- W4200343207 title "Matrix metalloproteinases and tissue inhibitors of metalloproteinases in murine β-coronavirus-induced neuroinflammation" @default.
- W4200343207 cites W1497871021 @default.
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- W4200343207 cites W1963618966 @default.
- W4200343207 cites W1964370299 @default.
- W4200343207 cites W1971168306 @default.
- W4200343207 cites W1983551023 @default.
- W4200343207 cites W1983879753 @default.
- W4200343207 cites W1992550986 @default.
- W4200343207 cites W1992912936 @default.
- W4200343207 cites W2002771508 @default.
- W4200343207 cites W2005951184 @default.
- W4200343207 cites W2007539022 @default.
- W4200343207 cites W2013792255 @default.
- W4200343207 cites W2019723399 @default.
- W4200343207 cites W2021769399 @default.
- W4200343207 cites W2022962195 @default.
- W4200343207 cites W2025170735 @default.
- W4200343207 cites W2026618142 @default.
- W4200343207 cites W2040734574 @default.
- W4200343207 cites W2046153984 @default.
- W4200343207 cites W2050643697 @default.
- W4200343207 cites W2051534519 @default.
- W4200343207 cites W2057901089 @default.
- W4200343207 cites W2060212120 @default.
- W4200343207 cites W2070872710 @default.
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- W4200343207 cites W2132260239 @default.
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- W4200343207 doi "https://doi.org/10.1016/j.virol.2021.11.012" @default.
- W4200343207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34906793" @default.
- W4200343207 hasPublicationYear "2022" @default.
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