Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200344348> ?p ?o ?g. }
- W4200344348 abstract "Baicalein is a flavonoid extracted from the root of Scutellaria baicalensis (Chinese skullcap) and is consumed as part of this botanical dietary supplement to reduce oxidative stress, pain, and inflammation. We previously reported that baicalein can also modify receptor signaling through the progesterone receptor (PR) and glucocorticoid receptor (GR) in vitro, which is interesting due to the well-established roles of both PR and GR in reducing inflammation. To understand the effects of baicalein on PR and GR signaling in vivo in the uterus, ovariectomized CD-1 mice were treated with DMSO, progesterone (P4), baicalein, P4 with baicalein, and P4 with RU486, a PR antagonist, for a week. The uteri were collected for histology and RNA sequencing. Our results showed that baicalein attenuated the antiproliferative effect of P4 on luminal epithelium as well as on the PR target genes HAND2 and ZBTB16. Baicalein did not change levels of PR or GR RNA or protein in the uterus. RNA sequencing data indicated that many transcripts significantly altered by baicalein were regulated in the opposite direction by P4. Similarly, a large portion of GO/KEGG terms and GSEA gene sets were altered in the opposite direction by baicalein as compared to P4 treatment. Treatment of baicalein did not change body weight, organ weight, or blood glucose level. In summary, baicalein functioned as a PR antagonist in vivo and therefore may oppose P4 action under certain conditions such as uterine hyperplasia, fibroids, and uterine cancers." @default.
- W4200344348 created "2021-12-31" @default.
- W4200344348 creator A5014604392 @default.
- W4200344348 creator A5053760995 @default.
- W4200344348 creator A5064389466 @default.
- W4200344348 creator A5068141324 @default.
- W4200344348 creator A5068626380 @default.
- W4200344348 creator A5071304630 @default.
- W4200344348 creator A5090906107 @default.
- W4200344348 date "2021-12-22" @default.
- W4200344348 modified "2023-10-06" @default.
- W4200344348 title "The Flavonoid Baicalein Negatively Regulates Progesterone Target Genes in the Uterus in Vivo" @default.
- W4200344348 cites W1503437050 @default.
- W4200344348 cites W1936675889 @default.
- W4200344348 cites W1971689221 @default.
- W4200344348 cites W1980216613 @default.
- W4200344348 cites W1985664608 @default.
- W4200344348 cites W1986773182 @default.
- W4200344348 cites W1990498979 @default.
- W4200344348 cites W1994439119 @default.
- W4200344348 cites W1999738495 @default.
- W4200344348 cites W2013653552 @default.
- W4200344348 cites W2022967210 @default.
- W4200344348 cites W2023298070 @default.
- W4200344348 cites W2028525084 @default.
- W4200344348 cites W2031618333 @default.
- W4200344348 cites W2036058659 @default.
- W4200344348 cites W2041087817 @default.
- W4200344348 cites W2043529788 @default.
- W4200344348 cites W2050852960 @default.
- W4200344348 cites W2055104677 @default.
- W4200344348 cites W2058161683 @default.
- W4200344348 cites W2058683100 @default.
- W4200344348 cites W2060092135 @default.
- W4200344348 cites W2065643273 @default.
- W4200344348 cites W2079714684 @default.
- W4200344348 cites W2085603542 @default.
- W4200344348 cites W2100020671 @default.
- W4200344348 cites W2101742720 @default.
- W4200344348 cites W2110181729 @default.
- W4200344348 cites W2111317895 @default.
- W4200344348 cites W2125974556 @default.
- W4200344348 cites W2128032685 @default.
- W4200344348 cites W2134280534 @default.
- W4200344348 cites W2146770513 @default.
- W4200344348 cites W2149195292 @default.
- W4200344348 cites W2150730076 @default.
- W4200344348 cites W2167791591 @default.
- W4200344348 cites W2267486437 @default.
- W4200344348 cites W2322336991 @default.
- W4200344348 cites W2322517081 @default.
- W4200344348 cites W2341148711 @default.
- W4200344348 cites W2413834607 @default.
- W4200344348 cites W2462234146 @default.
- W4200344348 cites W2473631582 @default.
- W4200344348 cites W2526141956 @default.
- W4200344348 cites W2531201188 @default.
- W4200344348 cites W2554399613 @default.
- W4200344348 cites W2565414613 @default.
- W4200344348 cites W2568322374 @default.
- W4200344348 cites W2593448862 @default.
- W4200344348 cites W2593901982 @default.
- W4200344348 cites W2594745832 @default.
- W4200344348 cites W2734554626 @default.
- W4200344348 cites W2761513144 @default.
- W4200344348 cites W2795622516 @default.
- W4200344348 cites W2795885266 @default.
- W4200344348 cites W2796429112 @default.
- W4200344348 cites W2800244712 @default.
- W4200344348 cites W2892107807 @default.
- W4200344348 cites W2900863907 @default.
- W4200344348 cites W2917919886 @default.
- W4200344348 cites W2956629887 @default.
- W4200344348 cites W2969873517 @default.
- W4200344348 cites W2985785877 @default.
- W4200344348 cites W3007218156 @default.
- W4200344348 cites W3009045159 @default.
- W4200344348 cites W3022558870 @default.
- W4200344348 cites W3026807961 @default.
- W4200344348 cites W3033712710 @default.
- W4200344348 cites W3161719572 @default.
- W4200344348 cites W3162940903 @default.
- W4200344348 cites W3176429628 @default.
- W4200344348 cites W3189493229 @default.
- W4200344348 cites W3198803663 @default.
- W4200344348 cites W4231328135 @default.
- W4200344348 doi "https://doi.org/10.1021/acs.jnatprod.1c01008" @default.
- W4200344348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34935393" @default.
- W4200344348 hasPublicationYear "2021" @default.
- W4200344348 type Work @default.
- W4200344348 citedByCount "1" @default.
- W4200344348 countsByYear W42003443482023 @default.
- W4200344348 crossrefType "journal-article" @default.
- W4200344348 hasAuthorship W4200344348A5014604392 @default.
- W4200344348 hasAuthorship W4200344348A5053760995 @default.
- W4200344348 hasAuthorship W4200344348A5064389466 @default.
- W4200344348 hasAuthorship W4200344348A5068141324 @default.
- W4200344348 hasAuthorship W4200344348A5068626380 @default.
- W4200344348 hasAuthorship W4200344348A5071304630 @default.
- W4200344348 hasAuthorship W4200344348A5090906107 @default.