FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200344732> ?p ?o ?g. }

• W4200344732 endingPage "94" @default.
• W4200344732 startingPage "85" @default.
• W4200344732 abstract "Abstract Objective Myocardial infarction (MI) remains the leading cause of morbidity and mortality due partly to the limited regenerative capacity of cardiomyocytes to replace cardiomyocyte lost due to apoptosis. Inhibiting cardiomyocyte apoptosis is recognized as an effective therapeutic approach for MI. MicroRNAs (miRNAs, miRs), which regulate target genes at the post-transcriptional level, play a significant role in the regulation of cardiovascular diseases such as MI. MicroRNA-135b (miR-135b) has a protective effect on cardiomyocytes. However, the role of miR-135b in cardiomyocyte apoptosis in infarct myocardium needs further clarification. Methods We generated α-MHC-miR-135b transgenic mice to investigate the role of miR-135b in myocardial injury after MI. MiR-135b mimic and negative control (NC) were transfected into H 2 O 2 -induced cardiomyocytes to evaluate the effect of overexpression of miR-135b on the levels of reactive oxygen species (ROS) and apoptosis. Results Our results showed that overexpression of miR-135b had protective effect on cardiomyocyte injury both in vivo and in vitro. MiR-135b inhibited cardiomyocyte apoptosis and ROS generation, downregulated proapoptosis proteins (cleaved-caspase-3 and Bax), and increased anti-apoptosis protein (Bcl-2). Moreover, miR-135b showed an inhibitory effect on apoptosis-related protein target transient receptor potential vanilloid-type 4 (TRPV4) cation channel. Conclusion MiR-135b might be considered a new molecular target for potential replacement therapy as antiapoptotic cardioprotection in the setting of MI." @default.
• W4200344732 created "2021-12-31" @default.
• W4200344732 creator A5002273876 @default.
• W4200344732 creator A5011418238 @default.
• W4200344732 creator A5061810022 @default.
• W4200344732 creator A5065613315 @default.
• W4200344732 creator A5069094261 @default.
• W4200344732 creator A5069644434 @default.
• W4200344732 creator A5070822882 @default.
• W4200344732 date "2021-12-01" @default.
• W4200344732 modified "2023-10-16" @default.
• W4200344732 title "Overexpression of microRNA-135b-5p attenuates acute myocardial infarction injury through its anti-oxidant and anti-apptotic properties" @default.
• W4200344732 cites W1867433030 @default.
• W4200344732 cites W1902881336 @default.
• W4200344732 cites W1932006487 @default.
• W4200344732 cites W1988097514 @default.
• W4200344732 cites W1993298758 @default.
• W4200344732 cites W2020858662 @default.
• W4200344732 cites W2030094330 @default.
• W4200344732 cites W2070056663 @default.
• W4200344732 cites W2104112382 @default.
• W4200344732 cites W2165344509 @default.
• W4200344732 cites W2287030243 @default.
• W4200344732 cites W2332286287 @default.
• W4200344732 cites W2588439017 @default.
• W4200344732 cites W2588711175 @default.
• W4200344732 cites W2604185487 @default.
• W4200344732 cites W2615532448 @default.
• W4200344732 cites W2618079530 @default.
• W4200344732 cites W2945347902 @default.
• W4200344732 cites W2986375902 @default.
• W4200344732 cites W2999744331 @default.
• W4200344732 cites W3048227908 @default.
• W4200344732 cites W3102775855 @default.
• W4200344732 cites W3121379723 @default.
• W4200344732 doi "https://doi.org/10.2478/fzm-2021-0011" @default.
• W4200344732 hasPublicationYear "2021" @default.
• W4200344732 type Work @default.
• W4200344732 citedByCount "0" @default.
• W4200344732 crossrefType "journal-article" @default.
• W4200344732 hasAuthorship W4200344732A5002273876 @default.
• W4200344732 hasAuthorship W4200344732A5011418238 @default.
• W4200344732 hasAuthorship W4200344732A5061810022 @default.
• W4200344732 hasAuthorship W4200344732A5065613315 @default.
• W4200344732 hasAuthorship W4200344732A5069094261 @default.
• W4200344732 hasAuthorship W4200344732A5069644434 @default.
• W4200344732 hasAuthorship W4200344732A5070822882 @default.
• W4200344732 hasBestOaLocation W42003447321 @default.
• W4200344732 hasConcept C104317684 @default.
• W4200344732 hasConcept C126322002 @default.
• W4200344732 hasConcept C127561419 @default.
• W4200344732 hasConcept C145059251 @default.
• W4200344732 hasConcept C185592680 @default.
• W4200344732 hasConcept C190283241 @default.
• W4200344732 hasConcept C207001950 @default.
• W4200344732 hasConcept C2779676291 @default.
• W4200344732 hasConcept C48349386 @default.
• W4200344732 hasConcept C500558357 @default.
• W4200344732 hasConcept C502942594 @default.
• W4200344732 hasConcept C54009773 @default.
• W4200344732 hasConcept C54355233 @default.
• W4200344732 hasConcept C55493867 @default.
• W4200344732 hasConcept C71924100 @default.
• W4200344732 hasConcept C86803240 @default.
• W4200344732 hasConcept C95444343 @default.
• W4200344732 hasConcept C98274493 @default.
• W4200344732 hasConceptScore W4200344732C104317684 @default.
• W4200344732 hasConceptScore W4200344732C126322002 @default.
• W4200344732 hasConceptScore W4200344732C127561419 @default.
• W4200344732 hasConceptScore W4200344732C145059251 @default.
• W4200344732 hasConceptScore W4200344732C185592680 @default.
• W4200344732 hasConceptScore W4200344732C190283241 @default.
• W4200344732 hasConceptScore W4200344732C207001950 @default.
• W4200344732 hasConceptScore W4200344732C2779676291 @default.
• W4200344732 hasConceptScore W4200344732C48349386 @default.
• W4200344732 hasConceptScore W4200344732C500558357 @default.
• W4200344732 hasConceptScore W4200344732C502942594 @default.
• W4200344732 hasConceptScore W4200344732C54009773 @default.
• W4200344732 hasConceptScore W4200344732C54355233 @default.
• W4200344732 hasConceptScore W4200344732C55493867 @default.
• W4200344732 hasConceptScore W4200344732C71924100 @default.
• W4200344732 hasConceptScore W4200344732C86803240 @default.
• W4200344732 hasConceptScore W4200344732C95444343 @default.
• W4200344732 hasConceptScore W4200344732C98274493 @default.
• W4200344732 hasIssue "2" @default.
• W4200344732 hasLocation W42003447321 @default.
• W4200344732 hasOpenAccess W4200344732 @default.
• W4200344732 hasPrimaryLocation W42003447321 @default.
• W4200344732 hasRelatedWork W1999992556 @default.
• W4200344732 hasRelatedWork W2007280799 @default.
• W4200344732 hasRelatedWork W2163127022 @default.
• W4200344732 hasRelatedWork W2243808002 @default.
• W4200344732 hasRelatedWork W2340468396 @default.
• W4200344732 hasRelatedWork W2380107697 @default.
• W4200344732 hasRelatedWork W2417133490 @default.
• W4200344732 hasRelatedWork W2573992804 @default.
• W4200344732 hasRelatedWork W2592556364 @default.
• W4200344732 hasRelatedWork W2912683484 @default.

• next