Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200345663> ?p ?o ?g. }
- W4200345663 endingPage "142" @default.
- W4200345663 startingPage "136" @default.
- W4200345663 abstract "High mobility group box 1 (HMGB1) is an important chromatin protein and a pro-inflammatory molecule. Though shown to enhance target DNA binding by the Epstein-Barr virus (EBV) lytic switch protein ZEBRA, whether HMGB1 actually contributes to gammaherpesvirus biology is not known. In investigating the contribution of HMGB1 to the lytic phase of EBV, important for development of EBV-mediated diseases, we find that compared to latently-infected cells, lytic phase Burkitt lymphoma-derived cells and peripheral blood lytic cells during primary EBV infection express high levels of HMGB1. Our experiments place HMGB1 upstream of ZEBRA and reveal that HMGB1, through the NLRP3 inflammasome, sustains the expression of ZEBRA. These findings indicate that in addition to the NLRP3 inflammasome's recently discovered role in turning the EBV lytic switch on, NLRP3 cooperates with the danger molecule HMGB1 to also maintain ZEBRA expression, thereby sustaining the lytic signal." @default.
- W4200345663 created "2021-12-31" @default.
- W4200345663 creator A5007574497 @default.
- W4200345663 creator A5010903349 @default.
- W4200345663 creator A5014505626 @default.
- W4200345663 creator A5015173460 @default.
- W4200345663 creator A5017389509 @default.
- W4200345663 creator A5020207988 @default.
- W4200345663 creator A5037869057 @default.
- W4200345663 creator A5040956880 @default.
- W4200345663 creator A5070802733 @default.
- W4200345663 creator A5082835020 @default.
- W4200345663 date "2022-01-01" @default.
- W4200345663 modified "2023-10-14" @default.
- W4200345663 title "The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells" @default.
- W4200345663 cites W1756750202 @default.
- W4200345663 cites W1855274031 @default.
- W4200345663 cites W1972443740 @default.
- W4200345663 cites W1986675733 @default.
- W4200345663 cites W2015616819 @default.
- W4200345663 cites W2052908887 @default.
- W4200345663 cites W2063480117 @default.
- W4200345663 cites W2088155787 @default.
- W4200345663 cites W2090213064 @default.
- W4200345663 cites W2110190083 @default.
- W4200345663 cites W2110415017 @default.
- W4200345663 cites W2158668067 @default.
- W4200345663 cites W2162055035 @default.
- W4200345663 cites W2169049494 @default.
- W4200345663 cites W2518022196 @default.
- W4200345663 cites W2593244834 @default.
- W4200345663 cites W2790120427 @default.
- W4200345663 cites W2792452770 @default.
- W4200345663 cites W2794906623 @default.
- W4200345663 cites W2802497670 @default.
- W4200345663 cites W2887043640 @default.
- W4200345663 cites W2893567108 @default.
- W4200345663 cites W2911549495 @default.
- W4200345663 cites W2922022514 @default.
- W4200345663 cites W2950583464 @default.
- W4200345663 cites W2971099705 @default.
- W4200345663 cites W2998971367 @default.
- W4200345663 cites W3012314530 @default.
- W4200345663 cites W3136313043 @default.
- W4200345663 doi "https://doi.org/10.1016/j.virol.2021.12.002" @default.
- W4200345663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34922257" @default.
- W4200345663 hasPublicationYear "2022" @default.
- W4200345663 type Work @default.
- W4200345663 citedByCount "3" @default.
- W4200345663 countsByYear W42003456632022 @default.
- W4200345663 countsByYear W42003456632023 @default.
- W4200345663 crossrefType "journal-article" @default.
- W4200345663 hasAuthorship W4200345663A5007574497 @default.
- W4200345663 hasAuthorship W4200345663A5010903349 @default.
- W4200345663 hasAuthorship W4200345663A5014505626 @default.
- W4200345663 hasAuthorship W4200345663A5015173460 @default.
- W4200345663 hasAuthorship W4200345663A5017389509 @default.
- W4200345663 hasAuthorship W4200345663A5020207988 @default.
- W4200345663 hasAuthorship W4200345663A5037869057 @default.
- W4200345663 hasAuthorship W4200345663A5040956880 @default.
- W4200345663 hasAuthorship W4200345663A5070802733 @default.
- W4200345663 hasAuthorship W4200345663A5082835020 @default.
- W4200345663 hasBestOaLocation W42003456631 @default.
- W4200345663 hasConcept C159047783 @default.
- W4200345663 hasConcept C182615771 @default.
- W4200345663 hasConcept C203014093 @default.
- W4200345663 hasConcept C2522874641 @default.
- W4200345663 hasConcept C2776914184 @default.
- W4200345663 hasConcept C2777209026 @default.
- W4200345663 hasConcept C2779338263 @default.
- W4200345663 hasConcept C2780545709 @default.
- W4200345663 hasConcept C2781375147 @default.
- W4200345663 hasConcept C54355233 @default.
- W4200345663 hasConcept C552990157 @default.
- W4200345663 hasConcept C83640560 @default.
- W4200345663 hasConcept C86803240 @default.
- W4200345663 hasConcept C95444343 @default.
- W4200345663 hasConceptScore W4200345663C159047783 @default.
- W4200345663 hasConceptScore W4200345663C182615771 @default.
- W4200345663 hasConceptScore W4200345663C203014093 @default.
- W4200345663 hasConceptScore W4200345663C2522874641 @default.
- W4200345663 hasConceptScore W4200345663C2776914184 @default.
- W4200345663 hasConceptScore W4200345663C2777209026 @default.
- W4200345663 hasConceptScore W4200345663C2779338263 @default.
- W4200345663 hasConceptScore W4200345663C2780545709 @default.
- W4200345663 hasConceptScore W4200345663C2781375147 @default.
- W4200345663 hasConceptScore W4200345663C54355233 @default.
- W4200345663 hasConceptScore W4200345663C552990157 @default.
- W4200345663 hasConceptScore W4200345663C83640560 @default.
- W4200345663 hasConceptScore W4200345663C86803240 @default.
- W4200345663 hasConceptScore W4200345663C95444343 @default.
- W4200345663 hasLocation W42003456631 @default.
- W4200345663 hasLocation W42003456632 @default.
- W4200345663 hasOpenAccess W4200345663 @default.
- W4200345663 hasPrimaryLocation W42003456631 @default.
- W4200345663 hasRelatedWork W1512641202 @default.
- W4200345663 hasRelatedWork W2018457864 @default.
- W4200345663 hasRelatedWork W2042712871 @default.