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- W4200348535 endingPage "876" @default.
- W4200348535 startingPage "863" @default.
- W4200348535 abstract "Recombinant nanoworms are promising candidates for materials and biomedical applications ranging from the templated synthesis of nanomaterials to multivalent display of bioactive peptides and targeted delivery of theranostic agents. However, molecular design principles to synthesize these assemblies (which are thermodynamically favorable only in a narrow region of the phase diagram) remain unclear. To advance the identification of design principles for the programmable assembly of proteins into well-defined nanoworms and to broaden their stability regimes, we were inspired by the ability of topologically engineered synthetic macromolecules to acess rare mesophases. To test this design principle in biomacromolecular assemblies, we used post-translational modifications (PTMs) to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, we show that the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. Importantly, we demonstrate that the judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms, which undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli." @default.
- W4200348535 created "2021-12-31" @default.
- W4200348535 creator A5018218412 @default.
- W4200348535 creator A5022722506 @default.
- W4200348535 creator A5034237670 @default.
- W4200348535 creator A5049273074 @default.
- W4200348535 creator A5051035066 @default.
- W4200348535 creator A5080141945 @default.
- W4200348535 date "2021-12-23" @default.
- W4200348535 modified "2023-10-17" @default.
- W4200348535 title "Adaptive Recombinant Nanoworms from Genetically Encodable Star Amphiphiles" @default.
- W4200348535 cites W1031578623 @default.
- W4200348535 cites W1547937637 @default.
- W4200348535 cites W1928869890 @default.
- W4200348535 cites W1976499671 @default.
- W4200348535 cites W1976672416 @default.
- W4200348535 cites W1987134040 @default.
- W4200348535 cites W1989270637 @default.
- W4200348535 cites W2000966264 @default.
- W4200348535 cites W2003618149 @default.
- W4200348535 cites W2016841036 @default.
- W4200348535 cites W2021520922 @default.
- W4200348535 cites W2029667189 @default.
- W4200348535 cites W2035266068 @default.
- W4200348535 cites W2037312364 @default.
- W4200348535 cites W2057477511 @default.
- W4200348535 cites W2060030489 @default.
- W4200348535 cites W2068846148 @default.
- W4200348535 cites W2068863639 @default.
- W4200348535 cites W2073047768 @default.
- W4200348535 cites W2081693079 @default.
- W4200348535 cites W2083850482 @default.
- W4200348535 cites W2088477804 @default.
- W4200348535 cites W2094458603 @default.
- W4200348535 cites W2124159149 @default.
- W4200348535 cites W2154792548 @default.
- W4200348535 cites W2154939912 @default.
- W4200348535 cites W2161331122 @default.
- W4200348535 cites W2170711116 @default.
- W4200348535 cites W2172559773 @default.
- W4200348535 cites W2206954826 @default.
- W4200348535 cites W2229999029 @default.
- W4200348535 cites W2295124130 @default.
- W4200348535 cites W2312543650 @default.
- W4200348535 cites W2313394576 @default.
- W4200348535 cites W2321503435 @default.
- W4200348535 cites W2327774501 @default.
- W4200348535 cites W2329098197 @default.
- W4200348535 cites W2332588081 @default.
- W4200348535 cites W2339366361 @default.
- W4200348535 cites W2340194832 @default.
- W4200348535 cites W2460255279 @default.
- W4200348535 cites W2519708471 @default.
- W4200348535 cites W2555870966 @default.
- W4200348535 cites W2573340532 @default.
- W4200348535 cites W2575862094 @default.
- W4200348535 cites W2580946867 @default.
- W4200348535 cites W2586666822 @default.
- W4200348535 cites W2586976801 @default.
- W4200348535 cites W2588697507 @default.
- W4200348535 cites W2612426099 @default.
- W4200348535 cites W2616313756 @default.
- W4200348535 cites W2748417965 @default.
- W4200348535 cites W2752537178 @default.
- W4200348535 cites W2768035349 @default.
- W4200348535 cites W2790132145 @default.
- W4200348535 cites W2793645622 @default.
- W4200348535 cites W2796781998 @default.
- W4200348535 cites W2800722845 @default.
- W4200348535 cites W2804846127 @default.
- W4200348535 cites W2884027472 @default.
- W4200348535 cites W2886876623 @default.
- W4200348535 cites W2896042546 @default.
- W4200348535 cites W2900580650 @default.
- W4200348535 cites W2904734978 @default.
- W4200348535 cites W2907601169 @default.
- W4200348535 cites W2910669154 @default.
- W4200348535 cites W2911844751 @default.
- W4200348535 cites W2917045576 @default.
- W4200348535 cites W2917522548 @default.
- W4200348535 cites W2918030007 @default.
- W4200348535 cites W2937039196 @default.
- W4200348535 cites W2943106036 @default.
- W4200348535 cites W2949837580 @default.
- W4200348535 cites W2952157403 @default.
- W4200348535 cites W2955312675 @default.
- W4200348535 cites W2966252953 @default.
- W4200348535 cites W2966261754 @default.
- W4200348535 cites W2976125873 @default.
- W4200348535 cites W2976736582 @default.
- W4200348535 cites W2995404081 @default.
- W4200348535 cites W3005465805 @default.
- W4200348535 cites W3008168035 @default.
- W4200348535 cites W3009464811 @default.
- W4200348535 cites W3012590976 @default.
- W4200348535 cites W3023198942 @default.
- W4200348535 cites W3028855498 @default.
- W4200348535 cites W3038867091 @default.