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- W4200355623 abstract "To realize clinical application of antibacterial photodynamic therapy (aPDT), one of the most arduous challenges is how to render aPDT agents high selectivity against bacterial pathogens. In light of the fact that amino group-containing lipids are rich on the outer surfaces of Gram-positive bacteria, we herein constructed an alkynyl-dangling ruthenium(II) polypyridine complex (Ru2) to preferentially label Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) over mammalian cells via the amino-yne bio-orthogonal click reaction. Thanks to the strong singlet oxygen generation ability, Ru2 could photo-inactivate S. aureus and MRSA effectively and specifically. Phosphatidylethanolamine (PE) molecules also exist in mammalian cells but are not accessible for Ru2, leading to its poor binding/uptake and negligible cytotoxicity in the dark and upon irradiation towards mammalian cells as well as low hemolysis, all favorable for aPDT application." @default.
- W4200355623 created "2021-12-31" @default.
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- W4200355623 date "2021-12-28" @default.
- W4200355623 modified "2023-10-14" @default.
- W4200355623 title "An Alkynyl‐Dangling Ru(II) Polypyridine Complex for Targeted Antimicrobial Photodynamic Therapy" @default.
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- W4200355623 doi "https://doi.org/10.1002/chem.202103359" @default.
- W4200355623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34890065" @default.
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